ArticleIntensive care medicine experimental2024
Six methods to determine expiratory time constants in mechanically ventilated patients: a prospective observational physiology study.
Article in Intensive care medicine experimental, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 2 citations in OpenAlex.
- Expiratory time constant patterns reveal obstructive lung mechanics in non-obstructive spirometry.PLOS digital health · 2026Article
- Article
- Respiratory pyramid interface (RPI): a conceptual three-dimensional pyramid model for visualization of lung mechanics during mechanical ventilation.Frontiers in physiology · 2026Article
- Expiratory Time Constants in Patients Undergoing Routine Spirometry.CHEST pulmonary · 2025Article
- Expiratory time constants in mechanically ventilated patients: rethinking the old concept-a narrative review.Intensive care medicine experimental · 2025Review
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExpiratory time constant (τ) objectively assesses the speed of exhalation and can guide adjustments of the respiratory rate and the I:E ratio with the goal of achieving complete exhalation. Multiple methods of obtaining τ are available, but they have not been compared. The purpose of this study was to compare six different methods to obtain τ and to test if the exponentially decaying flow corresponds to the measured time constants.
methodsIn this prospective study, pressure, flow, and volume waveforms of 30 postoperative patients undergoing volume (VCV) and pressure-controlled ventilation (PCV) were obtained using a data acquisition device and analyzed. τ was measured as the first 63% of the exhaled tidal volume (V
resultsMean (95% CI) measured τ was 0.59 (0.57-0.62) s and 0.60 (0.58-0.63) s for PCV and VCV (p = 0.45), respectively. Aerts method showed the shortest values of all methods for both modes: 0.57 (0.54-0.59) s for PCV and 0.58 (0.55-0.61) s for VCV. Calculated (C
conclusionAll six methods to determine τ show similar values and are feasible in postoperative mechanically ventilated patients in both PCV and VCV modes.
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