Evidence map›Paper›PMID 38451304›Full record

ArticleSchizophrenia bulletin2024

Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis.

Cassandra M J Wannan, Barnaby Nelson, Jean Addington, Kelly Allott, Alan Anticevic, Celso Arango, Justin T Baker, Carrie E Bearden, Tashrif Billah, Sylvain Bouix and 237 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. The problem of recognition of clinical high-risk states is hampering the prevention of schizophrenia.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

247 authors.

Cassandra M J WannanCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Barnaby NelsonCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Kelly AllottCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.ORCID 0000-0002-0640-4634
Alan AnticevicDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense, Madrid, Spain.
Justin T BakerDepartment of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA.
Carrie E BeardenDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-8516-923X
Tashrif BillahDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Sylvain BouixDepartment of Software Engineering and Information Technology, École de technologie supérieure, Montréal, Canada.
Matthew R BroomeSchool of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK.
Kate BuccilliCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Kristin S CadenheadDepartment of Psychiatry, University of California, San Diego, CA, USA.ORCID 0000-0002-5952-4605
Monica E CalkinsDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0546-0263
Tyrone D CannonDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Guillermo CecciIBM T.J. Watson Research Center, Yorktown Heights, NY, USA.ORCID 0000-0003-1013-8348
Eric Yu Hai ChenDepartment of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
Kang Ik K ChoDepartment Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Jimmy ChoiOlin Neuropsychiatry Research Center, Hartford Hospital, Hartford, CT, USA.
Scott R ClarkDiscipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.
Michael J ColemanDepartment Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Philippe ConusGeneral Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Cheryl M CorcoranDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Barbara A CornblattDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Covadonga M Diaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID 0000-0001-8538-3175
Dominic DwyerCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.ORCID 0000-0003-3949-5867
Bjørn H EbdrupCentre for Neuropsychiatric Schizophrenia Research, CNSR Mental Health Centre, Glostrup, Copenhagen, Denmark.
Lauren M EllmanDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Paolo Fusar-PoliDepartment of Psychosis Studies, King's College London, London, UK.
Liliana GalindoCambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Pablo A GasparDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Carla GerberBehavioral Health Services, PeaceHealth Medical Group, Eugene, OR, USA.
Louise Birkedal GlenthøjCopenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen, Denmark.
Robert GlynnDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Michael P HarmsDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Leslie E HortonDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
René S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Joseph KambeitzDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-8988-3959
Lana Kambeitz-IlankovicDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
John M KaneDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.ORCID 0000-0002-2628-9442
Tina KapurDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Matcheri S KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Sung-Wan KimDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.ORCID 0000-0002-6739-2163
Nikolaos KoutsoulerisDepartment of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany.
Marek KubickiDepartment Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Jun Soo KwonDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.ORCID 0000-0002-1060-1462
Kerstin LangbeinDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Kathryn E LewandowskiDepartment of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA.
Gregory A LightDepartment of Psychiatry, University of California, San Diego, CA, USA.
Daniel MamahDepartment of Psychiatry, Washington University Medical School, St. Louis, MO, USA.
Patricia J MarcyNorthwell Health, Glen Oaks, NY, USA.
Daniel H MathalonDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Patrick D McGorryCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Vijay A MittalDepartment of Psychology, Northwestern University, Evanston, IL, USA.ORCID 0000-0001-9017-5119
Merete NordentoftCopenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen, Denmark.
Angela NunezDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Ofer PasternakDepartment Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Godfrey D PearlsonDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Jesus PerezCAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Albert R PowersDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3057-5043
David R RoalfDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Fred W SabbPrevention Science Institute, University of Oregon, Eugene, OR, USA.
Jason SchiffmanDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
Jai L ShahPEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada.
Stefan SmesnyDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Jessica SparkCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
William S StoneDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2932-7288
Gregory P StraussDepartment of Psychology, University of Georgia, Athens, GA, USA.
Zailyn TamayoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
John TorousDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.ORCID 0000-0002-5362-7937
Rachel UpthegroveDepartment of Software Engineering and Information Technology, École de technologie supérieure, Montréal, Canada.
Mark VangelDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Swapna VermaDepartment of Psychosis, Institute of Mental Health, Singapore.
Jijun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Inge Winter-van RossumInstitute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Daniel H WolfDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Phillip WolffDepartment of Psychology, Emory University, Atlanta, GA, USA.
Stephen J WoodCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Alison R YungInstitute of Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC, Australia.
Carla AgurtoIBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
Mario Alvarez-JimenezCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Paul AmmingerCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Marco ArmandoYouth Early Detection/Intervention in Psychosis Platform (Plateforme ERA), Service of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital and The University of Lausanne, Lausanne, Switzerland.
Ameneh Asgari-TarghiDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
John CahillDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Ricardo E CarriónDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Eduardo CastroIBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
Suheyla Cetin-KarayumakDepartment Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
M Mallar ChakravartyDepartment of Psychiatry, McGill University, Montreal, Quebec, Canada.
Youngsun T ChoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
David CotterDepartment Psychiatry, Beaumont Hospital, Dublin 9, Ireland.
Simon D'AlfonsoSchool of Computing and Information Systems, The University of Melbourne, Parkville, VIC, Australia.
Michaela EnnisDepartment of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7898-8184
Shreyas FadnavisDepartment Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Clara FonteneauDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Caroline GaoCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.ORCID 0000-0002-0987-2759
Tina GuptaDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Raquel E GurDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ruben C GurDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Holly K HamiltonDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Gil D HoftmanDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Grace R JacobsDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Johanna JarchoDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Jie Lisa JiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Christian G KohlerDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Paris Alexandros LalousisSchool of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK.
Suzie LavoieCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Martin LepageDepartment of Psychiatry, McGill University, Montreal, Quebec, Canada.
Einat LiebenthalProgram for Specialized Treatment Early in Psychosis (STEP), CMHC, New Haven, CT, USA.
Josh MervisDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Vishnu MurtyDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Spero C NicholasDepartment of Psychiatry, Washington University Medical School, St. Louis, MO, USA.
Lipeng NingDepartment Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Nora PenzelDepartment Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Russell PoldrackDepartment of Psychology, Stanford University, Stanford, CA, USA.
Pablo PoloseckiIBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
Danielle N PrattDepartment of Psychology, Northwestern University, Evanston, IL, USA.
Rachel RabinPEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada.
Habiballah Rahimi EichiDepartment of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA.
Yogesh RathiDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Avraham ReichenbergDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jenna ReinenIBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
Jack RogersCentre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK.
Bernalyn Ruiz-YuDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Isabelle ScottCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Johanna Seitz-HollandDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Vinod H SrihariDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Agrima SrivastavaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew ThompsonCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Bruce I TuretskyDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Barbara C WalshDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Thomas WhitfordOrygen, Parkville, VIC, Australia.
Johanna T W WigmanDepartment of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center,Groningen, Netherlands.
Beier YaoDepartment of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA.
Hok Pan YuenCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Uzair AhmedOrygen, Parkville, VIC, Australia.
Andrew Jin Soo ByunDivision of Digital Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Yoonho ChungDepartment of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA.
Kim DoDepartment of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, Switzerland.
Larry HendricksCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Kevin HuynhCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Clark JeffriesRenaissance Computing Institute, University of North Carolina, Chapel Hill, NC, USA.
Erlend LaneDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Carsten LangholmDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Eric LinDepartment of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA.
Valentina MantuaDepartment of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
Gennarina SantorelliDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
Kosha RuparelDepartment of Psychology, Yale University, New Haven, CT, USA.
Eirini ZoupouDepartment of Psychology, Yale University, New Haven, CT, USA.
Tatiana AdasmeDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Lauren AddamoCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Laura AderyDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Munaza AliDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Andrea AutherDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Samantha AversaPEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada.
Seon-Hwa BaekDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
Kelly BatesDepartment of Psychology, Northwestern University, Evanston, IL, USA.
Alyssa BatheryDepartment of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
Johanna M M BayerCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Rebecca BeedhamCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Zarina BilgramiDepartment of Psychology, Emory University, Atlanta, GA, USA.
Sonia BirchCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Ilaria BonoldiDepartment of Psychosis Studies, King's College London, London, UK.
Owen BordersDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Renato BorgattiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Lisa BrownDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Alejandro BrunaDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Holly CarringtonDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Rolando I Castillo-PassiDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Justine ChenDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Nicholas ChengCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Ann Ee ChingCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Chloe CliffordSchool of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK.
Beau-Luke ColtonCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Pamela ContrerasDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Sebastián CorralDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Stefano DamianiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Monica DoneDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Andrés EstradéEarly Psychosis Detection and Clinical Intervention (EPIC) Lab, Department of Psychosis Studies, King's College London, London, UK.
Brandon Asika EtukaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Melanie FormicaCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Rachel FurlanDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Mia GeljicCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Carmela GermanoCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Ruth GetachewCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Mathias GoncalvesDepartment of Psychology, Stanford University, Stanford, CA, USA.
Anastasia HaidarDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jessica HartmannDepartment of Public Mental Health, Central Institute of Mental Health, Heidelberg Univeristy, Mannheim, Germany.
Anna JoDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
Omar JohnDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Sarah KerinsEarly Psychosis Detection and Clinical Intervention (EPIC) Lab, Department of Psychosis Studies, King's College London, London, UK.
Melissa KerrCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Irena KesselringDepartment of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
Honey KimDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
Nicholas KimDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kyle KinneyDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Marija KrcmarCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Elana KotlerDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Melanie LafanechereSchool of Psychology, University of Birmingham, Edgbaston, UK.
Clarice LeeCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Joshua LlerenaCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Christopher MarkiewiczDepartment of Psychology, Stanford University, Stanford, CA, USA.
Priya MatnejlNorthwell Health, Glen Oaks, NY, USA.
Alejandro MaturanaDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Aissata MavambuSchool of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK.
Rocío Mayol-TroncosoDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Amelia McDonnellDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Alessia McGowanDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Danielle McLaughlinNorthwell Health, Glen Oaks, NY, USA.
Rebecca McIlhennyDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Brittany McQueenCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Yohannes MebrahtuCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Martina MensiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Christy Lai Ming HuiDepartment of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
Yi Nam SuenDepartment of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
Stephanie Ming Yin WongDepartment of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
Neal MorrellCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Mariam OmarCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Alice PartridgeCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Christina PhassouliotisCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Anna PichiecchioDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Pierluigi PolitiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Christian PorterDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Umberto ProvenzaniDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Nicholas PrunierDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jasmine RajDepartment of Psychology, Northwestern University, Evanston, IL, USA.
Susan RayNorthwell Health, Glen Oaks, NY, USA.
Victoria RaynerCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Manuel ReyesDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Kate ReynoldsCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Sage RushDepartment of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
Cesar SalinasDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Jashmina ShettyCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Callum SnowballCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Sophie TodCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Gabriel Turra-FariñaDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Daniela ValleDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
Simone VealeDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Sarah WhitsonCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Alana WickhamDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Sarah YounCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Francisco ZamoranoUnidad de imágenes cuantitativas avanzadas, departamento de imágenes, clínica alemana, universidad del Desarrollo, Santiago, Chile.
Elissa ZavagliaPEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada.
Jamie ZinbergDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Scott W WoodsDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Martha E ShentonDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Funding

ProNET: Psychosis-Risk Outcomes NetworkU01MH124639 · NIMH · YALE UNIVERSITY · PI CARRIE E BEARDEN, JOHN M KANE · 2020 to 2026
$81.2M
Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination CenterU24MH124629 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI Rene S. Kahn, Martha E. Shenton · 2020 to 2026
$32.6M
Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)U01MH124631 · NIMH · UNIVERSITY OF MELBOURNE · PI Christopher Barnaby Nelson · 2020 to 2026
$30.4M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Medical Research Council MR/S037675/1NIMH NIH HHS U01 MH124631NIMH NIH HHS U01 MH124639NIMH NIH HHS U24 MH124629Wellcome Trust
6 · The paper itself

Abstract

This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.

Indexed as

Psychotic DisordersSchizophreniaAdolescentAdultFemaleHumansInternational CooperationMaleProdromal SymptomsProspective StudiesResearch DesignYoung Adultclinical high riskconsortiumearly detectionpredictionpreventionpsychosis

Identifiers

PMID38451304
PMCPMC11059785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.