Evidence map›Paper›PMID 38451281›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2024

Ostarine blunts the effect of endurance training on submaximal endurance in rats.

Veselin Vasilev, Nikolay Boyadjiev, Petar Hrischev, Fanka Gerginska, Slavi Delchev, Desislava Arabadzhiyska, Marina Komrakova, Kai O Boeker, Arndt F Schilling, Katerina Georgieva

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Veselin VasilevDepartment of Physiology, Faculty of Medicine, Medical University of Plovdiv, 15-A "Vasil Aprilov" Blvd, Plovdiv, 4002, Bulgaria. v_vasilev1892@abv.bg.
Nikolay BoyadjievDepartment of Physiology, Faculty of Medicine, Medical University of Plovdiv, 15-A "Vasil Aprilov" Blvd, Plovdiv, 4002, Bulgaria.
Petar HrischevDepartment of Physiology, Faculty of Medicine, Medical University of Plovdiv, 15-A "Vasil Aprilov" Blvd, Plovdiv, 4002, Bulgaria.
Fanka GerginskaDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Plovdiv, 15-A "Vasil Aprilov" Blvd, Plovdiv, 4002, Bulgaria.
Slavi DelchevDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Plovdiv, 15-A "Vasil Aprilov" Blvd, Plovdiv, 4002, Bulgaria.
Desislava ArabadzhiyskaDepartment of Clinical Laboratory, Faculty of Medicine, Medical University of Plovdiv, 15-A "Vasil Aprilov" Blvd, Plovdiv, 4002, Bulgaria.
Marina KomrakovaDepartment of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Kai O BoekerDepartment of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Arndt F SchillingDepartment of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Katerina GeorgievaDepartment of Physiology, Faculty of Medicine, Medical University of Plovdiv, 15-A "Vasil Aprilov" Blvd, Plovdiv, 4002, Bulgaria.
Medical University Plovdiv · BGUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study is to study the effects of ostarine alone and in combination with endurance training in sexually mature, male Wistar rats. The rats were divided into a treadmill-trained group and a sedentary group. Half of each group received either ostarine or vehicle for 8 weeks (n = 10 each, in total n = 40). We examined some functional, hormonal, and anthropometric parameters and the myogenic gene expression of myostatin, insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor-A (VEGF-A) in m. gastrocnemius. Ostarine decreased submaximal endurance and increased myogenic gene expression of myostatin but had no effect on maximal time to exhaustion and grip strength. Training increased submaximal endurance, maximal time to exhaustion, and grip strength. Our results indicate that both exercise and ostarine treatment had no significant effects on serum levels of luteinizing hormone, follicle-stimulating hormone, and testosterone, or on the myogenic gene expression of IGF-1 and VEGF-A. Neither ostarine nor the training had a significant effect on the testis, liver, and heart weights. In conclusion, ostarine had no effect on anthropometric and hormonal parameters but increased the myostatin gene expression in muscle. The SARM treatment decreased submaximal endurance without affecting maximal time to exhaustion, and training increased both metrics.

Indexed as

Insulin-Like Growth Factor IMuscle, SkeletalMyostatinPhysical EnduranceRats, WistarVascular Endothelial Growth Factor AAnimalsEndurance TrainingMalePhysical Conditioning, AnimalRatsResins, PlantTestosteroneinsulin-like growth factor-1, ratInsulin-Like Growth Factor IMstn protein, ratMyostatinResins, PlantTestosteroneVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratEnduranceOstarineSARMsSubmaximal trainingTestosterone

Identifiers

PMID38451281
PMCPMC11422473
OpenAlexW4392557872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.