Evidence map›Paper›PMID 38451105›Full record

ArticleJournal of the Chinese Medical Association : JCMA2024

Comparison of the mesodermal differentiation potential between embryonic stem cells and scalable induced pluripotent stem cells.

En-Tung Tsai, Huan-Chin Tseng, Yu-Hao Liu, You-Ren Wu, Shih-Yuan Peng, Wei-Yi Lai, Yi-Ying Lin, Shih-Pin Chen, Shih-Hwa Chiou, Yi-Ping Yang and 1 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Chinese Medical Association : JCMA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

En-Tung TsaiInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Huan-Chin TsengDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Yu-Hao LiuDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
You-Ren WuInstitute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Shih-Yuan PengDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Wei-Yi LaiDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Yi-Ying LinDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Shih-Pin ChenInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Shih-Hwa ChiouDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Yi-Ping YangDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Yueh ChienDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem cells (MSCs) have promising potential in clinical application, whereas their limited amount and sources hinder their bioavailability. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have become prominent options in regenerative medicine as both possess the ability to differentiate into MSCs.

methodsRecently, our research team has successfully developed human leukocyte antigen (HLA)-homozygous iPSC cell lines with high immune compatibility, covering 13.5% of the Taiwanese population. As we deepen our understanding of the differences between these ESCs and HLA-homozygous iPSCs, our study focused on morphological observations and flow cytometry analysis of specific surface marker proteins during the differentiation of ESCs and iPSCs into MSCs.

resultsThe results showed no significant differences between the two pluripotent stem cells, and both of them demonstrated the equivalent ability to further differentiate into adipose, cartilage, and bone cells.

conclusionOur research revealed that these iPSCs with high immune compatibility exhibit the same differentiation potential as ESCs, enhancing the future applicability of highly immune-compatible iPSCs.

Indexed as

Cell DifferentiationEmbryonic Stem CellsInduced Pluripotent Stem CellsCells, CulturedHumansMesenchymal Stem CellsMesoderm

Identifiers

PMID38451105
PMCPMC12718896
OpenAlexW4392550834

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.