Evidence map›Paper›PMID 38451080›Full record

ArticleInfection and immunity2024

Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis.

Ananya Gupta, Shyamala Thirunavukkarasu, Javier Rangel-Moreno, Mushtaq Ahmed, Rosemary V Swanson, Stanley Kimbung Mbandi, Alan V Smrcka, Deepak Kaushal, Thomas J Scriba, Shabaana A Khader

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Ananya GuptaDepartment of Microbiology, The University of Chicago, Chicago, Illinois, USA.ORCID 0000-0001-7917-7877
Shyamala ThirunavukkarasuDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Javier Rangel-MorenoDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Mushtaq AhmedDepartment of Microbiology, The University of Chicago, Chicago, Illinois, USA.
Rosemary V SwansonDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Stanley Kimbung MbandiSouth African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Alan V SmrckaDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
Deepak KaushalSouthwest National Primate Research Centre (SNPRC) at Texas Biomedical Research Institute, San Antonio, Texas, USA.ORCID 0000-0003-3521-1257
Thomas J ScribaSouth African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Shabaana A KhaderDepartment of Microbiology, The University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-9545-4982
University of Chicago · USUniversity of Cape Town · ZAWashington University in St. Louis · USTexas Biomedical Research Institute · USUniversity of Michigan · USUniversity of Rochester Medical Center · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
ROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSISR01AI111914 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2015 to 2025
$11.1M
ROLE OF IL-17 IN PROTECTIVE VACCINE-INDUCED IMMUNE RESPONSES AGAINST TUBERCULOSISR01HL105427 · NHLBI · WASHINGTON UNIVERSITY · PI KHADER, SHABAANA A. · 2011 to 2025
$5.9M
Understanding and Manipulating Phospholipase C and G Protein beta gamma subunit Signaling NetworksR35GM127303 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alan V. Smrcka · 2018 to 2026
$4.8M
The Role of Group 3 Innate Lymphoid cells (ILC3) in TuberculosisR01AI134236 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, KHADER, SHABAANA A. · 2017 to 2021
$4.4M
COMMON IMMUNE CORRELATES OF RISK OF TB DISEASE IN ANIMAL MODELS AND HUMANSR01AI123780 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2016 to 2019
$2.9M
Novel IL-17 producing memory cells are key to vaccine-based immunity in the lungR00AI075106 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KHADER, SHABAANA A. · 2008 to 2009
$486k
NHLBI NIH HHS R01 HL105427NIAID NIH HHS R00 AI075106NIAID NIH HHS R01 AI111914NIAID NIH HHS R01 AI123780NIAID NIH HHS R01 AI134236NIGMS NIH HHS R35 GM127303NIH HHS P51 OD011133
6 · The paper itself

Abstract

Tuberculosis (TB) caused by

Indexed as

Mycobacterium tuberculosisPhosphoinositide Phospholipase CTuberculosisAnimalsHumansImmunity, InnateMacrophage ActivationMicePhosphoinositide Phospholipase Cphospholipase C epsilon1-phosphatidylinositol-45-bisphosphate phosphodiesterase epsilon-1 (PLCƐ1)tuberculosis

Identifiers

PMID38451080
PMCPMC11003233
OpenAlexW4392561797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.