ArticleDevelopment (Cambridge, England)2024
A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche.
Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Bloodhounds chasing the origin of blood cells.Trends in cell biology · 2025Review
- Article
- GATA Transcription Factors: A Cross-Road for Erythropoiesis, Neurodevelopment, and Synucleinopathies.Developmental neurobiology · 2025Review
- The molecular and cellular hematopoietic stem cell specification niche.Experimental hematology · 2024Review
- Learning interpretable causal networks from very large datasets, application to 400,000 medical records of breast cancer patients.iScience · 2024Article
- The evolving hematopoietic niche during development.Frontiers in molecular biosciences · 2024Review
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Authors and funding
20 authors.
Funding
Abstract
The first hematopoietic stem and progenitor cells (HSPCs) emerge in the Aorta-Gonad-Mesonephros (AGM) region of the mid-gestation mouse embryo. However, the precise nature of their supportive mesenchymal microenvironment remains largely unexplored. Here, we profiled transcriptomes of laser micro-dissected aortic tissues at three developmental stages and individual AGM cells. Computational analyses allowed the identification of several cell subpopulations within the E11.5 AGM mesenchyme, with the presence of a yet unidentified subpopulation characterized by the dual expression of genes implicated in adhesive or neuronal functions. We confirmed the identity of this cell subset as a neuro-mesenchymal population, through morphological and lineage tracing assays. Loss of function in the zebrafish confirmed that Decorin, a characteristic extracellular matrix component of the neuro-mesenchyme, is essential for HSPC development. We further demonstrated that this cell population is not merely derived from the neural crest, and hence, is a bona fide novel subpopulation of the AGM mesenchyme.
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