Evidence map›Paper›PMID 38450561›Full record

ArticleJournal of neurotrauma2024

Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (TRACK-TBI) Study.

John K Yue, Esther L Yuh, Mahmoud M Elguindy, Xiaoying Sun, Thomas A van Essen, Hansen Deng, Patrick J Belton, Gabriela G Satris, Justin C Wong, Alex B Valadka and 16 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 12 institutions in 2 countries.

John K YueDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Esther L YuhBrain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, California, USA.
Mahmoud M ElguindyDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Xiaoying SunBiostatistics Research Center, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, California, USA.
Thomas A van EssenDepartment of Neurological Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Hansen DengDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Patrick J BeltonDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Gabriela G SatrisDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Justin C WongDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Alex B ValadkaDepartment of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Frederick K KorleyDepartment of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Claudia S RobertsonDepartment of Neurological Surgery, Baylor College of Medicine, Houston, Texas, USA.
Michael A McCreaDepartment of Neurological Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Murray B SteinDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Ramon Diaz-ArrastiaDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Kevin K W WangCenter for Neurotrauma, Multiomics and Biomarkers, Morehouse School of Medicine, Atlanta, Georgia, USA.
Nancy R TemkinDepartments of Neurological Surgery and Biostatistics, University of Washington, Seattle, Washington, USA.
Anthony M DiGiorgioDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Phiroz E TaraporeDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Michael C HuangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Amy J MarkowitzDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Ava M PuccioDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Pratik MukherjeeBrain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, California, USA.
David O OkonkwoDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Sonia JainBiostatistics Research Center, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, California, USA.
Geoffrey T ManleyDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
San Francisco General Hospital · USUniversity of Pittsburgh Medical Center · USHuman Longevity (United States) · USBaylor College of Medicine · USLeiden University Medical Center · NLMedical College of Wisconsin · USMorehouse School of Medicine · USNeurological Surgery · USUniversity of California San Diego · USUniversity of Michigan · USUniversity of Pennsylvania · USUniversity of Washington · US

Funding

Transforming Research and Clinical Knowledge in Traumatic Brain InjuryU01NS086090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ-ARRASTIA, RAMON, GIACINO, JOSEPH THOMAS · 2013 to 2017
$19.1M
Transforming Traumatic Brain Injury Research and Clinical CareRC2NS069409 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANLEY, GEOFFREY T · 2009 to 2011
$4.3M
NINDS NIH HHS RC2 NS069409NINDS NIH HHS U01 NS086090
6 · The paper itself

Abstract

Isolated traumatic subarachnoid hemorrhage (tSAH) after traumatic brain injury (TBI) on head computed tomography (CT) scan is often regarded as a "mild" injury, with reduced need for additional workup. However, tSAH is also a predictor of incomplete recovery and unfavorable outcome. This study aimed to evaluate the characteristics of CT-occult intracranial injuries on brain magnetic resonance imaging (MRI) scan in TBI patients with emergency department (ED) arrival Glasgow Coma Scale (GCS) score 13-15 and isolated tSAH on CT. The prospective, 18-center Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (TRACK-TBI; enrollment years 2014-2019) enrolled participants who presented to the ED and received a clinically-indicated head CT within 24 h of TBI. A subset of TRACK-TBI participants underwent venipuncture within 24 h for plasma glial fibrillary acidic protein (GFAP) analysis, and research MRI at 2-weeks post-injury. In the current study, TRACK-TBI participants age ≥17 years with ED arrival GCS 13-15, isolated tSAH on initial head CT, plasma GFAP level, and 2-week MRI data were analyzed. In 57 participants, median age was 46.0 years [quartile 1 to 3 (Q1-Q3): 34-57] and 52.6% were male. At ED disposition, 12.3% were discharged home, 61.4% were admitted to hospital ward, and 26.3% to intensive care unit. MRI identified CT-occult traumatic intracranial lesions in 45.6% (26 of 57 participants; one additional lesion type: 31.6%; 2 additional lesion types: 14.0%); of these 26 participants with CT-occult intracranial lesions, 65.4% had axonal injury, 42.3% had subdural hematoma, and 23.1% had intracerebral contusion. GFAP levels were higher in participants with CT-occult MRI lesions compared with without (median: 630.6 pg/mL, Q1-Q3: [172.4-941.2] vs. 226.4 [105.8-436.1],

Indexed as

Brain Injuries, TraumaticMagnetic Resonance ImagingSubarachnoid Hemorrhage, TraumaticTomography, X-Ray ComputedAdultAgedFemaleGlasgow Coma ScaleHumansMaleMiddle AgedProspective Studiesdiagnosisglial fibrillary acidic proteinmedical decision-makingneuroimagingtraumatic brain injurytraumatic subarachnoid hemorrhage

Identifiers

PMID38450561
PMCPMC11564841
OpenAlexW4392553570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.