Evidence map›Paper›PMID 38450445›Full record

ArticlePsychological medicine2024

Associations between disturbed sleep and attenuated psychotic experiences in people at clinical high risk for psychosis.

M J C Formica, M Fuller-Tyszkiewicz, U Reininghaus, M Kempton, P Delespaul, L de Haan, B Nelson, A Mikocka-Walus, L Olive, S Ruhrmann and 9 more

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In one paragraph

Article in Psychological medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

M J C FormicaOrygen, Parkville, Australia.ORCID https://orcid.org/0000-0002-9681-5575
M Fuller-TyszkiewiczCentre for Social and Early Emotional Development, School of Psychology, Deakin University, Geelong, Australia.
U ReininghausDepartment of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
M KemptonDepartment of Psychosis Studies, Institute of Psychiatry, Psychology, King's College London, London, UK.
P DelespaulFacalty of Health, Medicine and Life Sciences, Psychiatrie & Neuropsychologie, Maastricht University, Maastricht, The Netherlands.
L de HaanDepartment of Psychiatry, Early Psychosis, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
B NelsonOrygen, Parkville, Australia.
A Mikocka-WalusCentre for Social and Early Emotional Development, School of Psychology, Deakin University, Geelong, Australia.
L OliveOrygen, Parkville, Australia.
S RuhrmannDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
B RuttenDepartment of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience (MHeNS), European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
A Riecher-RösslerMedical Faculty, University of Basel, Basel, Switzerland.
G SachsMedical University of Vienna, Vienna, Austria.
L ValmaggiaDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
M van der GaagDepartment of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands.
P McGuireDepartment of Psychiatry, University of Oxford, Warneford Hospital OX3 7JX, UK.
J van OsDepartment of Psychiatry, Utrecht University Medical Centre, Utrecht, The Netherlands.
EU-GEI High-Risk Study
J A HartmannOrygen, Parkville, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPre-diagnostic stages of psychotic illnesses, including 'clinical high risk' (CHR), are marked by sleep disturbances. These sleep disturbances appear to represent a key aspect in the etiology and maintenance of psychotic disorders. We aimed to examine the relationship between self-reported sleep dysfunction and attenuated psychotic symptoms (APS) on a day-to-day basis.

methodsSeventy-six CHR young people completed the Experience Sampling Methodology (ESM) component of the European Union Gene-Environment Interaction Study, collected through PsyMate® devices, prompting sleep and symptom questionnaires 10 times daily for 6 days. Bayesian multilevel mixed linear regression analyses were performed on time-variant ESM data using the

resultsTwo of the seven psychosis variables were unidirectionally predicted by previous night's number of awakenings: every unit increase in number of nightly awakenings predicted a 0.27 and 0.28 unit increase in feeling unreal or paranoid the next day, respectively. No other sleep variables credibly predicted next-day psychotic symptoms or vice-versa.

conclusionIn this study, the relationship between sleep disturbance and APS appears specific to the item in question. However, some APS, including perceptual disturbances, had low levels of endorsement amongst this sample. Nonetheless, these results provide evidence for a unidirectional relationship between sleep and some APS in this population.

Indexed as

Psychotic DisordersSleep Wake DisordersAdolescentAdultBayes TheoremEcological Momentary AssessmentFemaleGene-Environment InteractionHumansMaleProdromal SymptomsSelf ReportSurveys and QuestionnairesYoung Adultearly interventionetiologyexperience sampling methodologypsychotic symptomssleep disturbance

Identifiers

PMID38450445
PMCPMC11413346

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.