Evidence map›Paper›PMID 38450259›Full record

ReviewNarra J2023

Application of CRISPR-Cas9 genome editing technology in various fields: A review.

Arif Nm Ansori, Yulanda Antonius, Raden Jk Susilo, Suhailah Hayaza, Viol D Kharisma, Arli A Parikesit, Rahadian Zainul, Vikash Jakhmola, Taru Saklani, Maksim Rebezov and 4 more

Abstract readReview
In one paragraph

Review in Narra J, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arif Nm AnsoriDepartment of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Yulanda AntoniusFaculty of Biotechnology, Universitas Surabaya, Surabaya, Indonesia.
Raden Jk SusiloNanotechology Engineering Study Program, Faculty of Advanced Technology and Multidiscipline, Universitas Airlangga, Surabaya, Indonesia.
Suhailah HayazaNanotechology Engineering Study Program, Faculty of Advanced Technology and Multidiscipline, Universitas Airlangga, Surabaya, Indonesia.
Viol D KharismaDoctoral Program of Mathematics and Natural Sciences, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Arli A ParikesitDepartment of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences (i3L), Jakarta,Indonesia.
Rahadian ZainulDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, Indonesia.
Vikash JakhmolaUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
Taru SaklaniUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
Maksim RebezovDepartment of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, Russian Federation.
Md Emdad UllahDepartment of Chemistry, Mississippi State University, Mississippi, United States.
Nikolai MaksimiukInstitute of Medical Education, Yaroslav-the-Wise Novgorod State University, Velikiy Novgorod, Russian Federation.
Marina DerkhoInstitute of Veterinary Medicine, South Ural State Agrarian University, Troitsk, Russian Federation.
Pavel BurkovInstitute of Veterinary Medicine, South Ural State Agrarian University, Troitsk, Russian Federation.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR-Cas9 has emerged as a revolutionary tool that enables precise and efficient modifications of the genetic material. This review provides a comprehensive overview of CRISPR-Cas9 technology and its applications in genome editing. We begin by describing the fundamental principles of CRISPR-Cas9 technology, explaining how the system utilizes a single guide RNA (sgRNA) to direct the Cas9 nuclease to specific DNA sequences in the genome, resulting in targeted double-stranded breaks. In this review, we provide in-depth explorations of CRISPR-Cas9 technology and its applications in agriculture, medicine, environmental sciences, fisheries, nanotechnology, bioinformatics, and biotechnology. We also highlight its potential, ongoing research, and the ethical considerations and controversies surrounding its use. This review might contribute to the understanding of CRISPR-Cas9 technology and its implications in various fields, paving the way for future developments and responsible applications of this transformative technology.

Indexed as

CRISPR-Cas9genome editingmedicinemolecular biologymolecular genetics

Identifiers

PMID38450259
PMCPMC10916045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.