Evidence map›Paper›PMID 38449905›Full record

ReviewNarra J2022

Monkeypox: Immune response, vaccination and preventive efforts.

Youdiil Ophinni, Andri Frediansyah, Salin Sirinam, Dewi Megawati, Ana M Stoian, Seyi S Enitan, Richard Y Akele, Ranjit Sah, Krit Pongpirul, Ziad Abdeen and 17 more

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Narra J, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 23 countries.

Youdiil OphinniRagon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
Andri FrediansyahPRTPP-National Research and Innovation Agency (BRIN), Yogyakarta, Indonesia.
Salin SirinamDepartment of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Dewi MegawatiDepartment of Veterinary Pathobiology, School of Veterinary Medicine, University of Missouri, Columbia, MO, United States.
Ana M StoianDepartment of Medical Microbiology and Immunology, School of Medicine, University of California Davis, CA, United States.
Seyi S EnitanDepartment of Medical Laboratory Science, Babcock University, Ilishan-Remo, Nigeria.
Richard Y AkeleDepartment of Biomedical Science, School of Applied Science, University of Brighton, London, United Kingdom.
Ranjit SahTribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal.
Krit PongpirulFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Ziad AbdeenDepartment of Community Health, Faculty of Medicine, Al-Quds University, Jerusalem.
Sevda AghayevaDepartment of Gastroenterology, Baku Medical Plaza Hospital, Baku, Azerbaijan.
Aamer IkramNational Institute of Heath, Islamabad, Pakistan.
Yohannes KebedeDepartment of Health, Behavior and Society, Faculty of Public Health, Jimma University, Jimma, Ethiopia.
Uwe WollinaDepartment of Dermatology and Allergology, Städtisches Klinikum Dresden, Dresden, Germany.
Kannan SubbaramSchool of Medicine, The Maldives National University, Maldives.
Ai KoyanagiResearch and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Barcelona, Spain.
Abdulwahed Al SerouriYemen Field Epidemiology Training Program, Sana'a, Yemen.
H Blaise Nguendo-YongsiDepartment of Epidemiology, School of Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon.
Jeffrey EdwardsMedical Research Foundation of Trinidad and Tobago, Port of Spain, Trinidad.
Dina E SallamDepartment of Pediatrics and Pediatric Nephrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Yousef KhaderThe Center of Excellence for Applied Epidemiology, The Eastern Mediterranean Public Health Network (EMPHNET), Amman, Jordan.
Sandro G Viveiros-RosaNational Institute of Industrial Property, Rio de Janeiro, Rio de Janeiro, Brazil.
Ziad A MemishResearch & Innovation Centre, King Saud Medical City, Ministry of Health, Riyadh, Kingdom of Saudi Arabia.
Mehrdad Amir-BehghadamiIranian Center of Excellence in Health Management, Department of Health Service Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran.
Sandro VentoFaculty of Medicine, University of Puthisastra, Phnom Penh, Cambodia.
Marius RademakerClinical Trial New Zealand, Waikato Hospital Campus, Hamilton, New Zealand.
Malik SallamDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman, Jordan.
Ain Shams University · EGAlfaisal University · SAAl-Quds University · PSAzerbaijan Medical University · AZBabcock University · NGCatholic University of Central Africa · CMCentro de Investigación Biomédica en Red de Salud Mental · ESEastern Mediterranean Public Health Network · JOInstituto Nacional da Propriedade Industrial · BRJimma University · ETJohns Hopkins University · USMahidol University · THMaldives National University · MVMissouri College · USNational Institute of Health · PKNational Nuclear Energy Agency of Indonesia · IDRagon Institute of MGH, MIT and Harvard · USStädtisches Klinikum Dresden · DETabriz University of Medical Sciences · IRTribhuvan University Teaching Hospital · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious threats to humans are continuously emerging. The 2022 worldwide monkeypox outbreak is the latest of these threats with the virus rapidly spreading to 106 countries by the end of September 2022. The burden of the ongoing monkeypox outbreak is manifested by 68,000 cumulative confirmed cases and 26 deaths. Although monkeypox is usually a self-limited disease, patients can suffer from extremely painful skin lesions and complications can occur with reported mortalities. The antigenic similarity between the smallpox virus (variola virus) and monkeypox virus can be utilized to prevent monkeypox using smallpox vaccines; treatment is also based on antivirals initially designed to treat smallpox. However, further studies are needed to fully decipher the immune response to monkeypox virus and the immune evasion mechanisms. In this review we provide an up-to-date discussion of the current state of knowledge regarding monkeypox virus with a special focus on innate immune response, immune evasion mechanisms and vaccination against the virus.

Indexed as

emerging viral infectious diseaseMonkeypox virusMPXVoutbreakzoonosis

Identifiers

PMID38449905
PMCPMC10914130
OpenAlexW4307023602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.