Evidence map›Paper›PMID 38449883›Full record

ArticleFrontiers in medicine2024

Expression of microRNAs related to apoptosis in the aqueous humor and lens capsule of patients with glaucoma.

Hyo Seon Yu, Eun Hee Hong, Ji Hye Kang, Yong Woo Lee, Won June Lee, Min Ho Kang, Heeyoon Cho, Yong Un Shin, Mincheol Seong

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Hyo Seon Yu *Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Eun Hee Hong *Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Ji Hye KangDepartment of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Yong Woo LeeDepartment of Ophthalmology, Kangwon National University Graduate School of Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea.
Won June LeeDepartment of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Min Ho KangDepartment of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Heeyoon ChoDepartment of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Yong Un ShinDepartment of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Mincheol SeongDepartment of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Hanyang University · KRHanyang University Guri Hospital · KRHanyang University Seoul Hospital · KRKangwon National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of this study is to investigate the expression profiles of microRNAs (miRNAs) related to apoptosis in the aqueous humor (AH) and lens capsule (LC) of patients with glaucoma. Methods: AH and LC samples were collected from patients with open-angle glaucoma and control participants who were scheduled for cataract surgery. A miRNA PCR array comprising 84 miRNAs was used to analyze the AH (glaucoma, Results: Expression levels of 19 and 3 miRNAs were significantly upregulated in the AH and LC samples of the glaucoma group, respectively ( Conclusion: This is the first study to investigate the differential expression of apoptosis-related miRNAs in the AH and LC of patients with glaucoma. Hsa-miR-193a-5p and hsa-miR-222-3p, which were upregulated in both AH and LC, may be considered potential biomarkers for glaucoma.

Indexed as

aqueous humorbiomarkerglaucomalens capsulemicroRNA

Identifiers

PMID38449883
PMCPMC10917207
OpenAlexW4391818658

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.