Evidence map›Paper›PMID 38449868›Full record

ArticleFrontiers in immunology2024

The nuclear pore protein NUP98 impedes LTR-driven basal gene expression of HIV-1, viral propagation, and infectivity.

Kumaraswami Chintala, Sriram Yandrapally, Warisha Faiz, Chhaya Rani Kispotta, Satarupa Sarkar, Krishnaveni Mishra, Sharmistha Banerjee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 16 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kumaraswami ChintalaDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Sriram Yandrapally *Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Warisha Faiz *Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Chhaya Rani KispottaDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Satarupa SarkarDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Krishnaveni MishraDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Sharmistha BanerjeeDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
University of Hyderabad · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleoporins (NUPs) are cellular effectors of human immunodeficiency virus-1 (HIV-1) replication that support nucleocytoplasmic trafficking of viral components. However, these also non-canonically function as positive effectors, promoting proviral DNA integration into the host genome and viral gene transcription, or as negative effectors by associating with HIV-1 restriction factors, such as MX2, inhibiting the replication of HIV-1. Here, we investigated the regulatory role of NUP98 on HIV-1 as we observed a lowering of its endogenous levels upon HIV-1 infection in CD4

Indexed as

HIV-1Nuclear Pore Complex ProteinsGene ExpressionHIV Long Terminal RepeatHumansNuclear Porenuclear pore complex protein 98Nuclear Pore Complex ProteinsHIV-1 LTRnuclear pore complexesNUP98transcriptionviral gene expression

Identifiers

PMID38449868
PMCPMC10914986
OpenAlexW4392001821

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.