Evidence map›Paper›PMID 38449863›Full record

ReviewFrontiers in immunology2024

Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update.

Tousif Ahmed Hediyal, C Vichitra, Nikhilesh Anand, Mahendran Bhaskaran, Saeefh M Essa, Pravir Kumar, M Walid Qoronfleh, Mohammed Akbar, Ruchika Kaul-Ghanekar, Arehally M Mahalakshmi and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  14. Nutrients · 2025
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  16. Towards EffectiveInternational journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 5 countries.

Tousif Ahmed HediyalDepartment of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, KA, India.
C VichitraDepartment of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, KA, India.
Nikhilesh AnandDepartment of Pharmacology, American University of Antigua, College of Medicine, Saint John's, Antigua and Barbuda.
Mahendran BhaskaranCollege of Pharmacy and Pharmaceutical Sciences, Frederic and Mary Wolf Centre University of Toledo, Health Science, Toledo, OH, United States.
Saeefh M EssaDepartment of Computer Science, Northwest High School, Bethesda, MD, United States.
Pravir KumarMolecular Neuroscience and Functional Genomics Laboratory, Department of Biotechnology, Delhi Technological University (Formerly DCE), Delhi, India.
M Walid QoronflehQ3CG Research Institute (QRI), Research and Policy Division, Ypsilanti, MI, United States.
Mohammed AkbarDivision of Neuroscience and Behavior, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, United States.
Ruchika Kaul-GhanekarSymbiosis Centre for Research and Innovation (SCRI), Cancer Research Lab, Symbiosis School of Biological Sciences (SSBS), Symbiosis International University (SIU), Pune, Maharashtra, India.
Arehally M MahalakshmiDepartment of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, KA, India.
Jian YangDrug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.
Byoung-Joon SongSection of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Bio-physics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, United States.
Tanya M MonaghanNational Institute for Health Research Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom.
Meena Kishore SakharkarDrug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.
Saravana Babu ChidambaramDepartment of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, KA, India.
JSS Academy of Higher Education and Research · INNational Institutes of Health · USUniversity of Saskatchewan · CAAmerican University of Antigua · AGDelhi Technological University · INNottingham Biomedical Research Centre · GBSymbiosis International University · INUniversity of Toledo · US

Funding

Alcohol Metabolism, Functional Consequences, Apoptosis Signaling Pathways, and Organ DamageZIAAA000036 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI SONG, BYOUNG-JOON · 2009 to 2025
$14.8M
6 · The paper itself

Abstract

The bidirectional communication between the gut and brain or gut-brain axis is regulated by several gut microbes and microbial derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide, and lipopolysaccharides. The Gut microbiota (GM) produce neuroactives, specifically neurotransmitters that modulates local and central neuronal brain functions. An imbalance between intestinal commensals and pathobionts leads to a disruption in the gut microbiota or dysbiosis, which affects intestinal barrier integrity and gut-immune and neuroimmune systems. Currently, fecal microbiota transplantation (FMT) is recommended for the treatment of recurrent

Indexed as

Ischemic StrokeNervous System DiseasesParkinson DiseaseStrokeFecal Microbiota TransplantationHumansfecal microbiota transplantationgut-brain axisgut microbiotaimmune cellsischemic strokeneuroimmune axisneuroinflammationneurological disorders

Identifiers

PMID38449863
PMCPMC10915229
OpenAlexW4392001865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.