Evidence map›Paper›PMID 38449839›Full record

ArticleGenetics research2024

HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia.

Maria Tizu, Bogdan Calenic, Mihai Hârza, Bogdan M Cristea, Ion Maruntelu, Andreea M Caragea, Adriana Talangescu, Alina Dima, Alexandra E Constantinescu, Ileana Constantinescu

Open access · goldAbstract read
In one paragraph

Article in Genetics research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Maria TizuImmunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 258 Fundeni Avenue, Bucharest 022328, Romania.ORCID 0009-0009-5202-4657
Bogdan CalenicImmunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 258 Fundeni Avenue, Bucharest 022328, Romania.ORCID 0000-0002-7565-9964
Mihai HârzaImmunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 258 Fundeni Avenue, Bucharest 022328, Romania.
Bogdan M CristeaImmunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 258 Fundeni Avenue, Bucharest 022328, Romania.ORCID 0000-0002-3839-2199
Ion MarunteluCentre of Immunogenetics and Virology, Fundeni Clinical Institute, 258 Fundeni Avenue, Bucharest 022328, Romania.ORCID 0000-0002-4284-8654
Andreea M CarageaImmunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 258 Fundeni Avenue, Bucharest 022328, Romania.ORCID 0000-0001-9290-5533
Adriana TalangescuCentre of Immunogenetics and Virology, Fundeni Clinical Institute, 258 Fundeni Avenue, Bucharest 022328, Romania.ORCID 0009-0002-9721-5915
Alina DimaColentina Clinical Hospital, Rheumatology Department Bucharest, 19-21 Stefan Cel Mare Street, Bucharest 020125, Romania.ORCID 0000-0001-8743-3236
Alexandra E ConstantinescuImmunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 258 Fundeni Avenue, Bucharest 022328, Romania.
Ileana ConstantinescuImmunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 258 Fundeni Avenue, Bucharest 022328, Romania.ORCID 0000-0002-3404-7240
Carol Davila University of Medicine and Pharmacy · ROInstitutul Clinic Fundeni · ROSpitalul Clinic Colentina · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: This study included 66 patients with CLL, diagnosed between 2020 and 2022, and 100 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQA1/DQB1/DPA1/DPB1, and HLA-DRB1/3/4/5) were investigated using next-generation sequencing technology. Results: Several HLA alleles were strongly associated with CLL. The most important finding was that HLA-DRB1 Conclusions: Our data are the first to indicate that in Romanian patients with CLL, the HLA-A

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellFemaleHLA-A AntigensHLA-DRB1 ChainsHLA-DRB3 ChainsHumansMalePolymorphism, GeneticRomaniaHLA-A AntigensHLA-DRB1 ChainsHLA-DRB3 Chains

Identifiers

PMID38449839
PMCPMC10917483
OpenAlexW4392241152

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.