Evidence map›Paper›PMID 38449811›Full record

ReviewFrontiers in pharmacology2024

The dual effect of endoplasmic reticulum stress in digestive system tumors and intervention of Chinese botanical drug extracts: a review.

Jinlong Zhang, Yanyu Chen, Bo Chen, Dajuan Sun, Zhen Sun, Junwei Liang, Jing Liang, Xin Xiong, Hua Yan

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jinlong ZhangShandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Yanyu ChenBeijing University of Chinese Medicine, Beijing, China.
Bo ChenShandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Dajuan SunAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Zhen SunAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Junwei LiangAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Jing LiangAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Xin XiongAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Hua YanAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine · CNShandong University of Traditional Chinese Medicine · CNBeijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoplasmic reticulum (ER) homeostasis is essential for maintaining human health, and once imbalanced, it will trigger endoplasmic reticulum stress (ERS), which participates in the development of digestive system tumors and other diseases. ERS has dual effect on tumor cells, activating adaptive responses to promote survival or inducing apoptotic pathways to accelerate cell death of the tumor. Recent studies have demonstrated that Chinese botanical drug extracts can affect the tumor process of the digestive system by regulating ERS and exert anticancer effects. This article summarizes the dual effect of ERS in the process of digestive system tumors and the intervention of Chinese botanical drug extracts in recent years, as reference for the combined treatment of digestive system tumors with Chinese and modern medicine.

Indexed as

Chinese botanical drugdigestive system tumordual effectendoplasmic reticulum stressunfolded protein response

Identifiers

PMID38449811
PMCPMC10917068
OpenAlexW4391994213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.