Evidence map›Paper›PMID 38448918›Full record

ArticleTrials2024

The effect of UNIMMAP multiple micronutrient supplements versus iron-folic acid and placebo in anemia reduction among women of reproductive age in Kebribeyah Woreda, Somali Regional State, Ethiopia: a study protocol for a community-based individual RCT.

Desalegn Kuche, Zeweter Abebe, Masresha Tessema, Meron Girma, Alemayehu Hussen, Kaleab Baye, Barbara J Stoecker

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05682261 (The Effect of Multiple Micronutrient Supplements in Reducing Anemia Among Women of Reproductive Age Compared to Iron-folic Acid at Kebribeyah District in Somali Regional State, Ethiopia- A Community-based Individual Randomized Control Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05682261 nacompletednot on this map

The Effect of Multiple Micronutrient Supplements in Reducing Anemia Among Women of Reproductive Age Compared to Iron-folic Acid at Kebribeyah District in Somali Regional State, Ethiopia- A Community-based Individual Randomized Control Trial

TypeinterventionalSponsorEthiopian Public Health InstituteRan2023 to 2023Enrolled265ConditionsAnemiaArmsUNIMMAP-MMS, IFA, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Desalegn KucheEthiopian Public Health Institute, Addis Ababa, Ethiopia. desukuche@gmail.com.ORCID http://orcid.org/0000-0001-7118-8352
Zeweter AbebeAddis Ababa University, Addis Ababa, Ethiopia.
Masresha TessemaEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Meron GirmaEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Alemayehu HussenEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Kaleab BayeAddis Ababa University, Addis Ababa, Ethiopia.
Barbara J StoeckerOklahoma State University, Stillwater, OK, USA.
Ethiopian Public Health Institute · ETAddis Ababa University · ETOklahoma State University · US

Funding

European Union Delegation to Ethiopia 2017/387-643
6 · The paper itself

Abstract

backgroundWomen of reproductive age (WRA) in developing countries are often at risk of micronutrient deficiencies due to inadequate intakes and excessive losses.

objectiveThe purpose of this trial is to assess the effectiveness of United Nations International Multiple Micronutrient Antenatal Preparation-Multiple Micronutrient Supplements (UNIMMAP-MMS) versus iron-folic acid (IFA) among WRA in reducing anemia.

methodsThree parallel groups of WRA will participate in a community-based, individually randomized, double-blinded, placebo-controlled superiority trial. After consent, the sample of 375 mildly or moderately anemic women based on hemoglobin by Hemocue will be randomly assigned across two interventions and one control arm. Trial participants in intervention arms will receive UNIMMAP-MMS or IFA while those in the control arm will receive placebos twice a week for 17 weeks. The primary outcome will be a change in mean hemoglobin (Hb) concentrations. Outcome assessors and study participants will be blinded to the type of supplements and study arm. DISCUSSION: The World Health Organization (WHO) added UNIMMAP-MMS to its essential medicine lists in 2021 but recommended rigorous study. Several factors in addition to inadequate intakes of iron and folic acid contribute to the high prevalence of anemia among WRA in the Somali region. The findings of this study will provide evidence on the effect of UNIMMAP-MMS and IFA on Hb concentrations and anemia prevalence among anemic WRA.

trial registrationClinicalTrials.gov NCT05682261. Registered on January 12, 2023.

Indexed as

AnemiaEquivalence Trials as TopicEthiopiaFemaleFolic AcidHemoglobinsHumansIronMicronutrientsPregnancyRandomized Controlled Trials as TopicSomaliaFolic AcidHemoglobinsIronMicronutrientsAnemiaIFATrialUNIMMAP-MMSWomen of reproductive age

Identifiers

PMID38448918
PMCPMC10916067
OpenAlexW4392517504

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.