ArticleAlzheimer's research & therapy2024
Heterogeneity and overlap in the continuum of linguistic profile of logopenic and semantic variants of primary progressive aphasia: a Profile Analysis based on Multidimensional Scaling study.
Article in Alzheimer's research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 15 citations in OpenAlex.
- Segmented profile analysis (SEPA): Plane-wise decomposition of within-person variation via ipsatized singular value decomposition.Behavior research methods · 2026Article
- FDG-PET in the Evaluation of Primary Progressive Aphasia: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Writing Abilities in Primary Progressive Aphasia: A Scoping Literature Review.Brain sciences · 2026Review
- Semantic control across Alzheimer's disease phenotypes: cognitive mechanisms and neural correlates.Frontiers in aging neuroscience · 2026Article
- Mapping the neural correlates of the effect of psycholinguistic variables on picture naming performance: a FDG-PET study across neurodegenerative diseases.Alzheimer's research & therapy · 2025Article
- Distinct cerebral perfusion patterns and linguistic profiles in Alzheimer's disease-related primary progressive aphasia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Psycholinguistic Variables and Spelling Accuracy for People with Logopenic Variant Primary Progressive Aphasia: A Cross-Sectional Study.Aphasiology · 2025Article
- Data-driven neuroanatomical subtypes of primary progressive aphasia.Brain : a journal of neurology · 2025Article
- The Functional Origin of Oral Word Production Deficits in the Logopenic Variant of Primary Progressive Aphasia: A Systematic Review.Brain sciences · 2025Review
- Clinical Manifestations and Neural Basis of Semantic Dementia: Converging Evidences From Brain Imaging Studies.Clinical interventions in aging · 2025Review
- Advancing Neuropsychological Rehabilitation in Primary Progressive Aphasia Based on Principles of Cognitive Neuroscience: A Scoping Review and Systematic Analysis of the Data.Brain sciences · 2024Article
- Primary Progressive Aphasia Lacking Core Features of Nonfluent and Semantic Variants: Clinical, Neuroimaging, and Neuropathologic Features.Neurology · 2024Observational
- A Critical Review of Noninvasive Brain Stimulation Technologies in Alzheimer's Dementia and Primary Progressive Aphasia.Journal of Alzheimer's disease : JAD · 2024Review
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Authors and funding
17 authors at 7 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary progressive aphasia (PPA) diagnostic criteria underestimate the complex presentation of semantic (sv) and logopenic (lv) variants, in which symptoms partially overlap, and mixed clinical presentation (mixed-PPA) and heterogenous profile (lvPPA +) are frequent. Conceptualization of similarities and differences of these clinical conditions is still scarce.
methodsLexical, semantic, phonological, and working memory errors from nine language tasks of sixty-seven PPA were analyzed using Profile Analysis based on Multidimensional Scaling, which allowed us to create a distributed representation of patients' linguistic performance in a shared space. Patients had been studied with [
resultsPatients' profiles were distributed across a continuum. All PPA, but two, presented a lexical retrieval impairment, in terms of reduced production of verbs and nouns. svPPA patients occupied a fairly clumped space along the continuum, showing a preponderant semantic deficit, which correlated to fusiform gyrus hypometabolism, while only few presented working memory deficits. Adjacently, lvPPA + presented a semantic impairment combined with phonological deficits, which correlated with metabolism in the anterior fusiform gyrus and posterior middle temporal gyrus. Starting from the shared phonological deficit side, a large portion of the space was occupied by all lvPPA, showing a combination of phonological, lexical, and working memory deficits, with the latter correlating with posterior temporo-parietal hypometabolism. Mixed PPA did not show unique profile, distributing across the space. DISCUSSION: Different clinical PPA entities exist but overlaps are frequent. Identifying shared and unique clinical markers is critical for research and clinical practice. Further research is needed to identify the role of genetic and pathological factors in such distribution, including also higher sample size of less represented groups.
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