Evidence map›Paper›PMID 38448893›Full record

ArticleBMC genomics2024

SNP-based and haplotype-based genome-wide association on drug dependence in Han Chinese.

Hanli Xu, Yulin Kang, Tingming Liang, Sifen Lu, Xiaolin Xia, Zuhong Lu, Lingming Hu, Li Guo, Lishu Zhang, Jiaqiang Huang and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 1 country.

Hanli Xu *College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing, 100028, China.
Yulin Kang *Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. kangyulin@craes.org.cn.
Tingming Liang *Jiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, Nanjing, 210023, China.
Sifen Lu *Precision Medicine Key Laboratory of Sichuan Province and Precision Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xiaolin XiaOffice of Academic Affairs, The National Police University for Criminal Justice, Baoding, 071000, China.
Zuhong LuSchool of Biological Science & Medical Engineering, Southeast University, Nanjing, 211189, China.
Lingming HuChinese Research Academy of Environmental Sciences, Beijing, 100012, China.
Li GuoSchool of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing, 210003, China.
Lishu ZhangCollege of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing, 100028, China.
Jiaqiang HuangCollege of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing, 100028, China.
Lin YeCheung Hong School of Journalism and Communication, Shantou University, Shantou, 515060, China.
Peiye JiangOffice of International Cooperation and Exchanges, Nanjing University, Nanjing, 210023, China.
Yi LiuJiangsu Taihu Institute of Addiction Rehabilitation, Suzhou, 215111, China.
Li XinyiCollege of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing, 100028, China.
Jin ZhaiDepartment of Social Work, Changzhou University, Changzhou, 213164, China.
Zi WangSchool of Music, Nanjing Normal University, Nanjing, 210097, China.
Yangyang LiuDepartment of Psychology, Nanjing University, Nanjing, 210023, China. liuyangyang661@sina.com.
Beijing Jiaotong University · CNNanjing Normal University · CNTianjin University of Technology and Education · CNChangzhou University · CNChinese Research Academy of Environmental Sciences · CNComputer Network Information Center · CNCriminal Investigation Police University of China · CNNanjing University · CNNanjing University of Posts and Telecommunications · CNShantou University · CNSichuan University · CNSoutheast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDrug addiction is a serious problem worldwide and is influenced by genetic factors. The present study aimed to investigate the association between genetics and drug addiction among Han Chinese.

methodsA total of 1000 Chinese users of illicit drugs and 9693 healthy controls were enrolled and underwent single nucleotide polymorphism (SNP)-based and haplotype-based association analyses via whole-genome genotyping.

resultsBoth single-SNP and haplotype tests revealed associations between illicit drug use and several immune-related genes in the major histocompatibility complex (MHC) region (SNP association: log

conclusionsThese findings provide new insights into risk-modeling and the prevention and treatment of methamphetamine and heroin dependence, which may further contribute to potential novel therapeutic approaches.

Indexed as

MethamphetamineSubstance-Related DisordersAldehyde Dehydrogenase, MitochondrialChinaGenome-Wide Association StudyHaplotypesHumansPolymorphism, Single NucleotideVitamin B 12Aldehyde Dehydrogenase, MitochondrialALDH2 protein, humanMethamphetamineVitamin B 12Drug addictionGenome-wide associationHan ChineseHaplotypeSingle nucleotide polymorphism

Identifiers

PMID38448893
PMCPMC10919046
OpenAlexW4392506739

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.