Evidence map›Paper›PMID 38448758›Full record

ArticleJournal of imaging informatics in medicine2024

Development and Validation of Multimodal Models to Predict the 30-Day Mortality of ICU Patients Based on Clinical Parameters and Chest X-Rays.

Jiaxi Lin, Jin Yang, Minyue Yin, Yuxiu Tang, Liquan Chen, Chang Xu, Shiqi Zhu, Jingwen Gao, Lu Liu, Xiaolin Liu and 4 more

Abstract readValidation Study
In one paragraph

Article in Journal of imaging informatics in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiaxi Lin *Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China.
Jin Yang *Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China.
Minyue Yin *Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China.
Yuxiu TangDepartment of Critical Care Medicine, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China.
Liquan ChenDepartment of Critical Care Medicine, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China.
Chang XuDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China.
Shiqi ZhuDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China.
Jingwen GaoDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China.
Lu LiuDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China.
Xiaolin LiuDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China.
Chenqi GuDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhou HuangDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yao WeiDepartment of Critical Care Medicine, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China. dr_betty@126.com.
Jinzhou ZhuDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Jiangsu, Suzhou 215006, China. jzzhu@zju.edu.cn.ORCID 0000-0003-0544-9248

Funding

National Natural Science Foundation of China 81801886National Natural Science Foundation of China 82000540Scientific research project of Jiangsu Provincial Health Commission M2020013Suzhou Clinical Center of Digestive Diseases Szlcyxzx202101Youth Program of Suzhou Health Committee KJXW2019001
6 · The paper itself

Abstract

We aimed to develop and validate multimodal ICU patient prognosis models that combine clinical parameters data and chest X-ray (CXR) images. A total of 3798 subjects with clinical parameters and CXR images were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database and an external hospital (the test set). The primary outcome was 30-day mortality after ICU admission. Automated machine learning (AutoML) and convolutional neural networks (CNNs) were used to construct single-modal models based on clinical parameters and CXR separately. An early fusion approach was used to integrate both modalities (clinical parameters and CXR) into a multimodal model named PrismICU. Compared to the single-modal models, i.e., the clinical parameter model (AUC = 0.80, F1-score = 0.43) and the CXR model (AUC = 0.76, F1-score = 0.45) and the scoring system APACHE II (AUC = 0.83, F1-score = 0.77), PrismICU (AUC = 0.95, F1 score = 0.95) showed improved performance in predicting the 30-day mortality in the validation set. In the test set, PrismICU (AUC = 0.82, F1-score = 0.61) was also better than the clinical parameters model (AUC = 0.72, F1-score = 0.50), CXR model (AUC = 0.71, F1-score = 0.36), and APACHE II (AUC = 0.62, F1-score = 0.50). PrismICU, which integrated clinical parameters data and CXR images, performed better than single-modal models and the existing scoring system. It supports the potential of multimodal models based on structured data and imaging in clinical management.

Indexed as

Intensive Care UnitsRadiography, ThoracicAgedFemaleHospital MortalityHumansMachine LearningMaleMiddle AgedNeural Networks, ComputerPrognosisAutomated machine learning (AutoML)Deep learningFeature fusionIntensive care unitMortalityMultimodal

Identifiers

PMID38448758
PMCPMC11300735

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.