Evidence map›Paper›PMID 38448730›Full record

Trial reportEuropean journal of applied physiology2024

New Zealand blackcurrant extract modulates the heat shock response in men during exercise in hot ambient conditions.

Nathan J Conrad, Emerson P Heckler, Ben J Lee, Garrett W Hill, Tessa R Flood, Lucy E V Wheeler, Rianne Costello, Ella F Walker, Trevor L Gillum, Mark E T Willems and 1 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of applied physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Nathan J ConradDepartment of Health & Human Performance, High Point University, One University Parkway, High Point, NC, 27268, USA.
Emerson P HecklerDepartment of Health & Human Performance, High Point University, One University Parkway, High Point, NC, 27268, USA.
Ben J LeeOccupational and Environmental Physiology Group, Centre for Physical Activity, Sport and Exercise Science, Coventry University, Coventry, England.
Garrett W HillDepartment of Health & Human Performance, High Point University, One University Parkway, High Point, NC, 27268, USA.
Tessa R FloodInstitute of Sport, Manchester Metropolitan University, Manchester, UK.
Lucy E V WheelerInstitute of Applied Sciences, University of Chichester, Chichester, UK.
Rianne CostelloGlobal Food Security Programme, Biotechnology and Biological Sciences Research Council, Swindon, UK.
Ella F WalkerDefence Science and Technology Laboratory, Porton Down, Salisbury, UK.
Trevor L GillumDepartment of Kinesiology, California Baptist University, Riverside, CA, USA.
Mark E T WillemsInstitute of Applied Sciences, University of Chichester, Chichester, UK.
Matthew R KuennenDepartment of Health & Human Performance, High Point University, One University Parkway, High Point, NC, 27268, USA. mkuennen@highpoint.edu.ORCID http://orcid.org/0000-0002-8677-786X
High Point University · USUniversity of Chichester · GBBiotechnology and Biological Sciences Research Council · GBCalifornia Baptist University · USDefence Science and Technology Laboratory · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine if 7d of New Zealand blackcurrant (NZBC) extract alters the heat shock, inflammatory and apoptotic response during prolonged exertional-heat stress.

methodsTen men (Age: 29 ± 2 years, Stature: 1.82 ± 0.02 m, Mass: 80.3 ± 2.7 kg, V̇O

resultseHSP32 was elevated at baseline in NZBC(+ 31%; p < 0.001). In PLACEBO HSP32 content in PBMC was elevated at 4-Post(+ 98%; p = 0.002), whereas in NZBC it fell at Post(- 45%; p = 0.030) and 1-Post(- 48%; p = 0.026). eHSP70 was increased at Post in PLACEBO(+ 55.6%, p = 0.001) and NZBC (+ 50.7%, p = 0.010). eHSP90 was increased at Post(+ 77.9%, p < 0.001) and 1-Post(+ 73.2%, p < 0.001) in PLACEBO, with similar increases being shown in NZBC (+ 49.0%, p = 0.006 and + 66.2%, p = 0.001; respectively). TLR4 and NF-κB were both elevated in NZBC at PRE(+ 54%, p = 0.003 and + 57%, p = 0.004; respectively). Main effects of study condition were also shown for BAX/BCL-2(p = 0.025) and Caspase 9 (p = 0.043); both were higher in NZBC.

conclusion7d of NZBC extract supplementation increased eHSP32 and PBMC HSP32 content. It also increased inflammatory and apoptotic markers in PBMC, suggesting that NZBC supports the putative inflammatory response that accompanies exertional-heat stress.

Indexed as

ApoptosisExerciseHeat-Shock ResponseHot TemperaturePlant ExtractsAdultHeat-Shock ProteinsHumansMaleRibesHeat-Shock ProteinsPlant ExtractsAnthocyaninsExerciseHeat shock proteinHyperthermiaSupplements

Identifiers

PMID38448730
PMCPMC11322260
OpenAlexW4392559656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.