ArticleScientific reports2024
Validation of computational fluid dynamics models for airway deposition with SPECT data of the same population.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Design and development of a high-throughput multipattern aerosol deposition device for respiratory toxicity and health-risk assessment (MARTHA).Journal of aerosol science · 2026Article
- Preclinical models of COPD: a state of the art review.The European respiratory journal · 2026Review
- Pulmonary Drug Delivery in the Era of Nanomedicine: From Biological Barriers to Artificial Intelligence-Driven Optimization.Pharmaceuticals (Basel, Switzerland) · 2026Review
- The Development of a Syringe-Based Insulin Applicator Using a Biodesign-Based Methodology.Biomimetics (Basel, Switzerland) · 2026Article
- Enhancing aerosol delivery in asthma and COPD: a comparison of MDI, valved holding chamber, and DPI systems using functional respiratory imaging (FRI).Scientific reports · 2026Article
- Response to the Letter to the Editor by Zambelli et al for In Silico Lung Deposition Profiles of Three Single-Inhaler Triple Therapies in Patients With COPD Using Functional Respiratory Imaging [Response To Letter].International journal of chronic obstructive pulmonary disease · 2026Article
- Advancing Tuberculosis Treatment with Next-Generation Drugs and Smart Delivery Systems.Pharmaceutics · 2026Review
- Tube2FEM: a general-purpose highly automated pipeline for flow-related processes in (embedded) tubular objects.Royal Society open science · 2025Article
- Lung Deposition of Extrafine Versus Nonextrafine Aerosols at Low Inhalation Flow Rates in Adult Asthma Patients: A Composition Study.Journal of aerosol medicine and pulmonary drug delivery · 2025Article
- Mechanistic Analysis of Fluid Dynamics and Multifactorial Impact Mechanisms in Inhaled Pharmaceutical Deposition for Chronic Respiratory Diseases.Bioengineering (Basel, Switzerland) · 2025Article
- Assessment of ventilation heterogeneity and particle deposition in asthmatics using combined SPECT/CT imaging and computational modeling approaches.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2025Article
- Regulatory and Industry Perspective on the Model Master File Framework for Locally Acting Drug Products.Pharmaceutical research · 2025Article
- iBCS: 4. Application of the Inhalation Biopharmaceutics Classification System to the Development of Orally Inhaled Drug Products.Molecular pharmaceutics · 2025Review
- Novel Approach Methodologies in Modeling Complex Bioaerosol Exposure in Asthma and Allergic Rhinitis Under Climate Change.Expert reviews in molecular medicine · 2025Review
- In Silico Lung Deposition Profiles of Three Single-Inhaler Triple Therapies in Patients with COPD Using Functional Respiratory Imaging.International journal of chronic obstructive pulmonary disease · 2025Article
- Subject-Specific Multi-Scale Modeling of the Fate of Inhaled Aerosols.Journal of aerosol science · 2025Article
- Rapid deposition analysis of inhaled aerosols in human airways.Scientific reports · 2024Article
- A Critical Analysis of the CFD-DEM Simulation of Pharmaceutical Aerosols Deposition in Upper Intra-Thoracic Airways: Considerations on Aerosol Transport and Deposition.Pharmaceutics · 2024Article
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Authors and funding
4 authors.
Funding
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Abstract
This study compared computational fluid dynamic (CFD) model predictions on aerosol deposition in six asthmatic patients to the in-vivo results of the same group. Patient-specific ventilation and internal air distribution were prescribed using inspiratory and expiratory CT scans of each patient, accounting for individual lobar air flow distribution. Moreover, the significant influence of realistic mouth and throat geometries on regional deposition is demonstrated. The in-vivo data were obtained from single photon emission computed tomography (SPECT) in 6 subjects with mild asthma selected from a database of historical clinical trials. The governing flow and particle tracking equations were solved numerically using a commercial CFD tool, and the modeled deposition results were compared to the SPECT data. Good agreement was found between the CFD model, applying k-ω SST turbulence model, and SPECT in terms of aerosol deposition. The average difference for the lobar deposition obtained from CFD model and SPECT/CT data was 2.1%. The high level of agreement is due to applying patient specific airway geometries and inspiratory/expiratory CT images, anatomical upper airways, and realistic airway trees. The results of this study show that CFD is a powerful tool to simulate patient-specific deposition if correct boundary conditions are applied and can generate similar information obtained with functional imaging tools, such as SPECT.
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