ArticleNature2024
Oxidative cyclization reagents reveal tryptophan cation-π interactions.
Erratum issuedAbstract read
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Scaling covalent ligand discovery through dynamic combinatorial library-versus-proteome screening.Nature communications · 2026Article
- Enzymatic Bromination of Native Peptides for Late-Stage Structural Diversification via Suzuki-Miyaura Coupling.ACS chemical biology · 2026Article
- Designer Aromatic Cations for Photoinduced Protein Ligation, Imaging, and Intracellular Labeling at Extended Wavelengths.Journal of the American Chemical Society · 2026Article
- Covalent Protein Inhibitors via Tyrosine and Tryptophan Conjugation with Cyclic Imine Mannich Electrophiles.Angewandte Chemie (International ed. in English) · 2026Article
- Exploring the Potential of Ultrafast Arylation for Capping Cysteine Residues with Fixed Charge Modifications.Journal of the American Society for Mass Spectrometry · 2026Article
- Cation-Cation Photosensitization for Protein Ligation and Intracellular Catalysis.Journal of the American Chemical Society · 2026Article
- Cysteine Reactivity Profiling Identifies Host Regulators ofACS infectious diseases · 2026Article
- Global profiling of arginine reactivity and ligandability in the human proteome.Nature chemistry · 2026Article
- Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity-Guided Approach.Chemical record (New York, N.Y.) · 2026Review
- Tryptophan Bioconjugation through Auxiliary Boron-Accelerated, Additive-Free Friedel-Crafts Alkylation.JACS Au · 2026Article
- Tryptophan Suppresses FTH1-Driven Ferritinophagy, a Key Correlate of Prognosis in Hepatocellular Carcinoma.Cell proliferation · 2026Article
- Chemoselective Histidine Bioconjugation Using Thiophosphorodichloridate Reagents.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Enzymatic bromination of native peptides for late-stage structural diversification via Suzuki-Miyaura coupling.bioRxiv : the preprint server for biology · 2025Article
- Profiling the proteome-wide selectivity of diverse electrophiles.Nature chemistry · 2025Article
- Designer Aromatic Cations for Photo-Induced Protein Ligation, Imaging, and Intracellular Labelling at Extended Wavelengths.bioRxiv : the preprint server for biology · 2025Article
- Cysteine reactivity profiling identifies host regulators ofbioRxiv : the preprint server for biology · 2025Article
- Late-Stage Aromatic C-H Bond Functionalization for Cysteine/Selenocysteine Bioconjugation.Journal of the American Chemical Society · 2025Article
- Advances in the chemical synthesis of human proteoforms.Science China. Life sciences · 2025Review
- Radical-Initiated Photodissociation at Tryptophan Residues within Intact Proteins in the Gas Phase.Journal of the American Chemical Society · 2025Article
- A glycan foldamer that uses carbohydrate-aromatic interactions to perform catalysis.Nature chemistry · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors.
Xiao Xie *Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Patrick J Moon *Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Steven W M CrossleyDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Amanda J BischoffDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Dan HeDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Gen LiDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Nam DaoDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Angel Gonzalez-ValeroDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-4341-7546
Audrey G ReevesDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Jeffrey M McKennaNovartis Institutes of Biomedical Research, Cambridge, MA, USA.ORCID 0000-0002-2978-5652
Susanna K ElledgeDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
James A WellsDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8267-5519
F Dean TosteDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA. fdtoste@berkeley.edu.ORCID 0000-0001-8018-2198
Christopher J ChangDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA. chrischang@berkeley.edu.ORCID 0000-0001-5732-9497
Funding
Molecular Imaging Probes To Study Redox BiologyR01GM079465 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2006 to 2026
$7.8MUniv of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5MMethods for Selective Organic Synthesis based on Ionic CatalystsR35GM118190 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI F. Dean Toste · 2016 to 2026
$6.7MSurfaceomic technologies and antibodies to probe cell surface proteomes and their interactomes at unprecedented small scale and high-resolutionR35GM122451 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAMES A WELLS · 2017 to 2026
$5.3MChemical Probes to Study Formaldehyde BiologyR01ES028096 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2017 to 2026
$4.1MResearch Training in Chemistry and Chemical BiologyT32GM145460 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason E Gestwicki · 2022 to 2026
$3.1MChemical Probes to Study Methionine Redox BiologyR01GM139245 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2020 to 2026
$2.9MHigh Definition Ion Mobility SpectrometerS10OD020062 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI WILLIAMS, EVAN R · 2015 to 2015
$590kAcquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265kNIEHS NIH HHS R01 ES028096NIGMS NIH HHS R01 GM079465NIGMS NIH HHS R01 GM139245NIGMS NIH HHS R35 GM118190NIGMS NIH HHS R35 GM122451NIGMS NIH HHS T32 GM066698NIGMS NIH HHS T32 GM145460NIH HHS S10 OD020062NIH HHS S10 OD024998
Abstract
Methods for selective covalent modification of amino acids on proteins can enable a diverse array of applications, spanning probes and modulators of protein function to proteomics
Indexed as
CationsCyclizationIndicators and ReagentsProteinsTryptophanClick ChemistryOxidation-ReductionPeptidesProteomeCationsIndicators and ReagentsPeptidesProteinsProteomeTryptophan
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.