ArticleNature2024
Genome-wide characterization of circulating metabolic biomarkers.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 5 of them syntheses that pooled it.
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0cells of the map it votes in
176citing papers in PubMed, 5 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
176 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Pooled it
- Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.Nature communications · 2026Pooled it
- Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes.Diabetes, obesity & metabolism · 2026Pooled it
- Integrated multi-omics mapping of the causal landscape of gout across the circulating-tissue axis.Frontiers in immunology · 2026Pooled it
- Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites.Cell genomics · 2025Pooled it
- Multi-omics Mendelian randomisation reveals distinct molecular drivers of pathological myopia complications vs simple myopia.Journal of global health · 2026Article
- Article
- Article
- Article
- Evaluating the causal effects of circulating metabolites on major depression disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- AI semantics for biomedical data integration.bioRxiv : the preprint server for biology · 2026Article
- APOC1-Associated VLDL-Pathway Dysregulation in Papillary Thyroid Carcinoma: A Reproducible Cross-Cohort Transcriptomic Signature Associated With the Diagnostic-to-Treatment Interval.Chemical biology & drug design · 2026Article
- A flexible framework for robust and efficient Mendelian randomization with debiasing.Briefings in bioinformatics · 2026Article
- Multi-omic characterization of the Hispanic/Latino blood lipidome reveals an additional locus and attenuated genetic prediction.HGG advances · 2026Article
- [Association between 473 gut microbiota and Alzheimer's disease: a Mendelian randomization mediation analysis of 233 circulating metabolites].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK-Mediated Metabolic Reprogramming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Plasma Metabolite Associations with Incident Heart Failure with Reduced and Preserved Ejection Fraction.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Mendelian-Randomization Study Reveals Causal Relationships Between Blood Metabolites and Psychiatric Disorders.Schizophrenia bulletin · 2026Article
116 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
90 authors.
Minna K Karjalainen *Systems Epidemiology, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland. minna.k.karjalainen@oulu.fi.ORCID 0000-0003-3184-3775
Savita Karthikeyan *British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Clare Oliver-WilliamsBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Eeva SlizSystems Epidemiology, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.ORCID 0000-0002-2316-058X
Elias AllaraBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1634-8330
Wing Tung FungBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Praveen SurendranBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Weihua ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0001-8279-3611
Pekka JousilahtiDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0001-7190-0979
Kati KristianssonDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0003-4688-107X
Veikko SalomaaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0001-7563-5324
Matt GoodwinMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
David A HughesMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID 0000-0002-9644-8998
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-6442-7754
Lilian Fernandes SilvaInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-0225-842X
Xianyong YinDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-6454-2384
Anubha MahajanWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Matt J NevilleNIHR Oxford Biomedical Research Centre, OUHFT Oxford, Oxford, UK.ORCID 0000-0002-6004-5433
Natalie R van ZuydamWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Ayse DemirkanSurrey Institute for People-Centred AI, University of Surrey, Guildford, UK.ORCID 0000-0002-7546-0867
Jun LiuNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0001-5288-3042
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-7801-809X
Stella TrompetDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-5006-0528
Zhengming ChenNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0001-6423-105X
Christiana KartsonakiNuffield Department of Population Health, University of Oxford, Oxford, UK.
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.ORCID 0000-0001-5873-7089
Kuang LinNuffield Department of Population Health, University of Oxford, Oxford, UK.
Fiona A HagenbeekDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-8773-0430
Jouke Jan HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-5668-2368
René PoolDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-5579-0933
M Arfan IkramDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0003-0372-8585
Joyce van MeursDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Toomas HallerInstitute of Genomics, University of Tartu, Tartu, Estonia.
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-3697-6617
Mika KähönenFinnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Pashupati P MishraFinnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Peter K JoshiCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0002-6361-5059
Erin Macdonald-DunlopCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-2167-7470
Jonas ZiererDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Ilhan E AcarDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.ORCID 0000-0002-2078-9905
Carel B HoyngDepartment of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.
Yara T E LechanteurDepartment of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.
Lude FrankeDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Alexander KurilshikovDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0003-2541-5627
Alexandra ZhernakovaDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Marian BeekmanSection of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-0585-6206
Erik B van den AkkerSection of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-7693-0728
Ivana KolcicDepartment of Public Health, School of Medicine, University of Split, Split, Croatia.
Ozren PolasekDepartment of Public Health, School of Medicine, University of Split, Split, Croatia.ORCID 0000-0002-5765-1862
Igor RudanCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
Christian GiegerResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0001-6986-9554
Melanie WaldenbergerResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0003-0583-5093
Folkert W AsselbergsAmsterdam University Medical Centers, Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands.
China Kadoorie Biobank Collaborative Group
Estonian Biobank Research Team
FinnGen
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9405-9550
Jingyuan FuDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0001-5578-1236
Anneke I den HollanderDepartment of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-0634-5408
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0001-9790-0571
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-9795-0365
James F WilsonCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0001-5751-9178
Terho LehtimäkiFinnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0002-2555-4427
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Tonu EskoInstitute of Genomics, University of Tartu, Tartu, Estonia.
Robin G WaltersNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-9179-0321
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-3246-8359
Naveed SattarSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID 0000-0002-1604-2593
Mohsen GhanbariDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-9476-7143
Ko Willems van DijkDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-2172-7394
Fredrik KarpeNIHR Oxford Biomedical Research Centre, OUHFT Oxford, Oxford, UK.ORCID 0000-0002-2751-1770
Mark I McCarthyWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-4393-0510
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-3394-7749
Marjo-Riitta JärvelinResearch Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0002-2149-0630
Nicholas J TimpsonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID 0000-0002-7141-9189
Markus PerolaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.ORCID 0000-0003-2086-4837
John C ChambersDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Cornelia van DuijnNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-2374-9204
P Eline SlagboomSection of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-2875-4723
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-7099-7972
John DaneshBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Mika Ala-KorpelaSystems Epidemiology, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.ORCID 0000-0001-5905-1206
Adam S ButterworthBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6915-9015
Johannes KettunenSystems Epidemiology, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.ORCID 0000-0002-3345-491X
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MIdentifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7MBritish Heart Foundation CH/1996001/9454Cancer Research UK 19169Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_17223Medical Research Council MC_PC_18026Medical Research Council MC_PC_19009Medical Research Council MC_UU_00007/10NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK062370Wellcome Trust 202802/Z/16/Z
Abstract
Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism
Indexed as
BiomarkersGenome-Wide Association StudyMetabolomicsAcetoneCholestasis, IntrahepaticCohort StudiesFemaleHumansHypertensionLipoproteinsMagnetic Resonance SpectroscopyMendelian Randomization AnalysisMetabolic Networks and PathwaysPhenotypePolymorphism, Single NucleotidePregnancyAcetoneBiomarkersLipoproteins
Identifiers
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