Evidence map›Paper›PMID 38448437›Full record

ArticleNature communications2024

Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation.

Myeongki Cho, Jeong-Kyu Han, Jungmin Suh, Jeong Jin Kim, Jae Ryun Ryu, In Sik Min, Mingyu Sang, Selin Lim, Tae Soo Kim, Kyubeen Kim and 10 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
18.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 67 citations in OpenAlex.

  1. Review
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  11. Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
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  20. Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 2 countries.

Myeongki Cho *Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Jeong-Kyu Han *Brain Science Institute, Korea Institute of Science and Technology, 5. Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.
Jungmin Suh *Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Jeong Jin KimDepartment of Electronics Engineering, Pusan National University, 2, Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan, 46241, Republic of Korea.ORCID 0009-0009-6987-1502
Jae Ryun RyuDepartment of Anatomy, College of Medicine, Korea University, 17-gil Koryodae-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
In Sik MinFunctional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.ORCID 0009-0003-0314-4915
Mingyu SangFunctional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Selin LimFunctional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Tae Soo KimFunctional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Kyubeen KimFunctional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Kyowon KangFunctional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Kyuhyun HwangSchool of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Kanghwan KimBrain Science Institute, Korea Institute of Science and Technology, 5. Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.
Eun-Bin HongCenter for Brain Function, Korea Institute of Science and Technology 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.
Min-Ho NamCenter for Brain Function, Korea Institute of Science and Technology 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.ORCID 0000-0002-6191-1268
Jongbaeg KimSchool of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.ORCID 0000-0003-4434-5871
Young Min SongSchool of Electrical Engineering and Computer Science (EECS), Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.ORCID 0000-0002-4473-6883
Gil Ju LeeDepartment of Electronics Engineering, Pusan National University, 2, Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan, 46241, Republic of Korea. gjlee0414@pusan.ac.kr.ORCID 0000-0003-2225-2738
Il-Joo ChoDepartment of Convergence Medicine, College of Medicine, Korea University, 17-gil Koryodae-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. ijcho@korea.ac.kr.ORCID 0000-0001-9016-6749
Ki Jun YuFunctional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. kijunyu@yonsei.ac.kr.ORCID 0000-0002-2922-2702
Yonsei University · KRKorea Institute of Science and Technology · KRGwangju Institute of Science and Technology · KRKorea Institute of Brain Science · KRKorea University · JPKorea University · KRPusan National University · KR

Funding

National Research Foundation of Korea (NRF) 2019M3E5D2A01063814National Research Foundation of Korea (NRF) NRF-2019H1A2A1077020National Research Foundation of Korea (NRF) NRF-2019R1A2C2086085National Research Foundation of Korea (NRF) NRF-2021R1A4A1031437National Research Foundation of Korea (NRF) NRF-2021R1A6A3A0108733912National Research Foundation of Korea (NRF) NRF-2021R1C1C2013605
6 · The paper itself

Abstract

Bioresorbable neural implants based on emerging classes of biodegradable materials offer a promising solution to the challenges of secondary surgeries for removal of implanted devices required for existing neural implants. In this study, we introduce a fully bioresorbable flexible hybrid opto-electronic system for simultaneous electrophysiological recording and optogenetic stimulation. The flexible and soft device, composed of biodegradable materials, has a direct optical and electrical interface with the curved cerebral cortex surface while exhibiting excellent biocompatibility. Optimized to minimize light transmission losses and photoelectric artifact interference, the device was chronically implanted in the brain of transgenic mice and performed to photo-stimulate the somatosensory area while recording local field potentials. Thus, the presented hybrid neural implant system, comprising biodegradable materials, promises to provide monitoring and therapy modalities for versatile applications in biomedicine.

Indexed as

Absorbable ImplantsCentral Nervous System DepressantsAnimalsArtifactsBrainElectronicsMiceMice, TransgenicOptogeneticsCentral Nervous System Depressants

Identifiers

PMID38448437
PMCPMC10917781
OpenAlexW4392508481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.