ArticleNature communications2024
In situ electrochemical regeneration of nanogap hotspots for continuously reusable ultrathin SERS sensors.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Scalable Fabrication of Highly Ordered Au/Ag Composite Nanoshell Array for Ultrasensitive SERS Detection of Trace Pesticides.Nanomaterials (Basel, Switzerland) · 2026Article
- Surface-Enhanced Raman Spectroscopy for Lithium Battery Interfaces.ChemSusChem · 2026Review
- Article
- In vivo dynamic hotspot-enhanced Raman spectroscopy via reconfigurable swarming nanoprobes.Nature communications · 2026Article
- Thermal transport through molecular monolayers in plasmonic nanogaps.Nature communications · 2026Article
- Next-Generation SERS Probes: Engineering Hotspots, Intelligent Molecular Targeting, and AI-Driven Spectral Analysis for Emerging Applications.Nanomaterials (Basel, Switzerland) · 2026Review
- Machine learning-enhanced identification of fluorophilic interactions for improved SERS detection of PFOA.Environmental science. Nano · 2026Article
- SERS and SEF with enhancement in nanogaps: from fabrication to biosensing.Nanoscale advances · 2026Review
- The optical nose: Monolayer sensitization of Au surfaces for plasmonic gas sensing.Science advances · 2026Article
- The role of Au-Cl adlayers in the Turkevich synthesis of gold nanoparticles.Chemical communications (Cambridge, England) · 2026Article
- Spatiotemporal Raman probing of molecular transport in sub-2-nm plasmonic quasi-2D nanochannels.Science advances · 2026Article
- Transient Au-Cl adlayers modulate the surface chemistry of gold nanoparticles during redox reactions.Nature chemistry · 2026Article
- Tracking and Controlling Monolayer Water in Gold Nanogaps using Extreme Plasmonic Spectroscopy.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Tracking Molecular Shear at Metal Surfaces Using Enhanced Lamb Wave Scattering in Plasmonic Nanocavities.Nano letters · 2025Article
- Enhancing glyphosate detection in rice by SERS: controlled aggregation of silver nanoparticles and carbon disulfide-mediated signal amplification.Food chemistry: X · 2025Article
- Plasmonic Molecular Entrapment for Label-Free Methylated DNA Detection and Machine-Learning Assisted Quantification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Novel High-Throughput Electrochemical Detection of Staphylococcus Aureus, Bacillus Cereus, or Micrococcus Luteus Using AuNPs@TiSmall (Weinheim an der Bergstrasse, Germany) · 2025Article
- A Microfluidic Device to Realize Electrochemically Controlled SERS Detection in HPLC.Analytical chemistry · 2025Article
- Requirements for fast multianalyte detection and characterisation via electrochemical-assisted SERS in a reusable and easily manufactured flow cell.Analytical and bioanalytical chemistry · 2025Article
- High-Efficiency SERS of 4-Mercaptobenzoic Acid and Biphenyl-4,4'-Dithiol via Nanoparticle-on-Mirror Plasmonic Nanocavities.Nanomaterials (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Surface-enhanced Raman spectroscopy (SERS) harnesses the confinement of light into metallic nanoscale hotspots to achieve highly sensitive label-free molecular detection that can be applied for a broad range of sensing applications. However, challenges related to irreversible analyte binding, substrate reproducibility, fouling, and degradation hinder its widespread adoption. Here we show how in-situ electrochemical regeneration can rapidly and precisely reform the nanogap hotspots to enable the continuous reuse of gold nanoparticle monolayers for SERS. Applying an oxidising potential of +1.5 V (vs Ag/AgCl) for 10 s strips a broad range of adsorbates from the nanogaps and forms a metastable oxide layer of few-monolayer thickness. Subsequent application of a reducing potential of -0.80 V for 5 s in the presence of a nanogap-stabilising molecular scaffold, cucurbit[5]uril, reproducibly regenerates the optimal plasmonic properties with SERS enhancement factors ≈10
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Registered trials
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