Evidence map›Paper›PMID 38448408›Full record

ArticleNature communications2024

Rectifying artificial nanochannels with multiple interconvertible permeability states.

Ruocan Qian, Mansha Wu, Zhenglin Yang, Yuting Wu, Weijie Guo, Zerui Zhou, Xiaoyuan Wang, Dawei Li, Yi Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ruocan Qian *Key Laboratory for Advanced Materials, East China University of Science and Technology, Shanghai, 200237, P. R. China. ruocanqian@ecust.edu.cn.ORCID 0000-0002-1039-9866
Mansha Wu *Key Laboratory for Advanced Materials, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Zhenglin YangDepartment of Chemistry, University of Texas at Austin, Austin, TX, 78712, USA.
Yuting WuDepartment of Chemistry, University of Texas at Austin, Austin, TX, 78712, USA.ORCID 0000-0003-3196-5916
Weijie GuoDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA.
Zerui ZhouKey Laboratory for Advanced Materials, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Xiaoyuan WangKey Laboratory for Advanced Materials, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Dawei LiKey Laboratory for Advanced Materials, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Yi LuDepartment of Chemistry, University of Texas at Austin, Austin, TX, 78712, USA. yi.lu@utexas.edu.ORCID 0000-0003-1221-6709
East China University of Science and Technology · CNThe University of Texas at Austin · US

Funding

Design and Selection of Novel Metalloenzymes for Biocatalysis, Bioimaging, and Genetic EngineeringR35GM141931 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Yi Lu · 2021 to 2026
$3.5M
NIGMS NIH HHS R35 GM141931
6 · The paper itself

Abstract

Transmembrane channels play a vital role in regulating the permeation process, and have inspired recent development of biomimetic channels. Herein, we report a class of artificial biomimetic nanochannels based on DNAzyme-functionalized glass nanopipettes to realize delicate control of channel permeability, whereby the surface wettability and charge can be tuned by metal ions and DNAzyme-substrates, allowing reversible conversion between different permeability states. We demonstrate that the nanochannels can be reversibly switched between four different permeability states showing distinct permeability to various functional molecules. By embedding the artificial nanochannels into the plasma membrane of single living cells, we achieve selective transport of dye molecules across the cell membrane. Finally, we report on the advanced functions including gene silencing of miR-21 in single cancer cells and selective transport of Ca

Indexed as

DNA, CatalyticBiomimeticsCell MembraneGene SilencingPermeabilityDNA, Catalytic

Identifiers

PMID38448408
PMCPMC10918189
OpenAlexW4392503911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.