Evidence map›Paper›PMID 38448160›Full record

ArticleLife science alliance2024

Phosphorylation of Rec8 cohesin complexes regulates mono-orientation of kinetochores in meiosis I.

Yu Liu, Yu Min, Yongxin Liu, Yoshinori Watanabe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Effects ofExperimental and therapeutic medicine · 2026
    Article
  2. Oocyte Kinetochores at the Nexus of Meiotic Drive and Segregation Fidelity.Advances in experimental medicine and biology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yu LiuSchool of Bioengineering, Jiangnan University, Wuxi, China.
Yu MinSchool of Bioengineering, Jiangnan University, Wuxi, China.
Yongxin LiuSchool of Bioengineering, Jiangnan University, Wuxi, China.ORCID 0009-0003-3121-4191
Yoshinori WatanabeScience Center for Future Foods, Jiangnan University, Wuxi, China ywatanabe@jiangnan.edu.cn.ORCID 0000-0002-5488-4812
Jiangnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In meiosis I, unlike in mitosis, sister kinetochores are captured by microtubules emanating from the same spindle pole (mono-orientation) and centromeric cohesion mediated by cohesin is protected in the following anaphase I. The conserved meiosis-specific kinetochore protein meikin (Moa1 in fission yeast) associates with polo-like kinase: Plo1 and regulates both mono-orientation and cohesion protection. Although the phosphorylation of Rec8-S450 by Plo1 associated with Moa1 plays a key role in cohesion protection, how Moa1-Plo1 regulates mono-orientation remains elusive. Here, we identify Plo1 phosphorylation sites in the cohesin subunits, Rec8 and Psm3. The non-phosphorylatable mutations at these sites showed specific defects in mono-orientation. These results enabled the genetic dissection of meikin functions at the centromeres.

Indexed as

SchizosaccharomycesSchizosaccharomyces pombe ProteinsCell Cycle ProteinsCentromereCohesinsKinetochoresMeiosisPhosphorylationProtein Serine-Threonine KinasesCell Cycle ProteinsCohesinsMoa1 protein, S pombePlo1 protein, S pombeProtein Serine-Threonine KinasesSchizosaccharomyces pombe Proteins

Identifiers

PMID38448160
PMCPMC10917647
OpenAlexW4392499975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.