Evidence map›Paper›PMID 38447974›Full record

Observational studyJournal of atherosclerosis and thrombosis2024

Elevated Leukocyte Count and Platelet-Derived Thrombogenicity Measured Using the Total Thrombus-Formation Analysis System in Patients with ST-Segment Elevation Myocardial Infarction.

Shinnosuke Kikuchi, Kengo Tsukahara, Shinya Ichikawa, Takeru Abe, Hidefumi Nakahashi, Yugo Minamimoto, Yuichiro Kimura, Eiichi Akiyama, Kozo Okada, Yasushi Matsuzawa and 8 more

Open access · diamondAbstract readObservational Study
In one paragraph

Observational study in Journal of atherosclerosis and thrombosis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Shinnosuke KikuchiDivision of Cardiology, Yokohama City University Medical Center.
Kengo TsukaharaDivision of Cardiology, Yokohama City University Medical Center.
Shinya IchikawaDivision of Cardiology, Yokohama City University Medical Center.
Takeru AbeAdvanced Critical Care and Emergency Center, Yokohama City University Medical Center.
Hidefumi NakahashiDivision of Cardiology, Yokohama City University Medical Center.
Yugo MinamimotoDivision of Cardiology, Yokohama City University Medical Center.
Yuichiro KimuraDivision of Cardiology, Yokohama City University Medical Center.
Eiichi AkiyamaDivision of Cardiology, Yokohama City University Medical Center.
Kozo OkadaDivision of Cardiology, Yokohama City University Medical Center.
Yasushi MatsuzawaDivision of Cardiology, Yokohama City University Medical Center.
Masaaki KonishiDivision of Cardiology, Yokohama City University Medical Center.
Nobuhiko MaejimaDivision of Cardiology, Yokohama City University Medical Center.
Noriaki IwahashiDivision of Cardiology, Yokohama City University Medical Center.
Masami KosugeDivision of Cardiology, Yokohama City University Medical Center.
Toshiaki EbinaDivision of Cardiology, Yokohama City University Medical Center.
Kouichi TamuraDepartment of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine.
Kazuo KimuraDivision of Cardiology, Yokohama City University Medical Center.
Kiyoshi HibiDivision of Cardiology, Yokohama City University Medical Center.
Yokohama City University · JPYokohama City University Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsHigh platelet-derived thrombogenicity during the acute phase of ST-segment elevation myocardial infarction (STEMI) is associated with poor outcomes; however, the associated factors remain unclear. This study aimed to examine whether acute inflammatory response after STEMI affects platelet-derived thrombogenicity.

methodsThis retrospective observational single-center study included 150 patients with STEMI who were assessed for platelet-derived thrombogenicity during the acute phase. Platelet-derived thrombogenicity was assessed using the area under the flow-pressure curve for platelet chip (PL-AUC), which was measured using the total thrombus-formation analysis system (T-TAS). The peak leukocyte count was evaluated as an acute inflammatory response after STEMI. The patients were divided into two groups: the highest quartile of the peak leukocyte count and the other three quartiles combined.

resultsPatients with a high peak leukocyte count (>15,222/mm

conclusionsAn elevated leukocyte count is associated with high T-TAS-based platelet-derived thrombogenicity during the acute phase of STEMI.

Indexed as

Blood PlateletsPercutaneous Coronary InterventionST Elevation Myocardial InfarctionThrombosisAgedFemaleFollow-Up StudiesHumansLeukocyte CountMaleMiddle AgedPrognosisRetrospective StudiesInflammationLeukocyte countPlatelet-derived thrombogenicityPrimary percutaneous coronary interventionST-segment elevation myocardial infarction

Identifiers

PMID38447974
PMCPMC11374560
OpenAlexW4392446564

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.