Evidence map›Paper›PMID 38447670›Full record

ArticleNature2024

The molecular basis of sugar detection by an insect taste receptor.

João Victor Gomes, Shivinder Singh-Bhagania, Matthew Cenci, Carlos Chacon Cordon, Manjodh Singh, Joel A Butterwick

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 47 citations in OpenAlex.

  1. The sensory biology of mosquito gustation.Current opinion in neurobiology · 2026
    Review
  2. Article
  3. Article
  4. A Molecular and Cellular Mechanism for Bitter Taste in the mosquitobioRxiv : the preprint server for biology · 2026
    Article
  5. The lepidopteran analyst: how caterpillars, moths and butterflies encode taste identity and valence.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Iridoids fromMolecules (Basel, Switzerland) · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Comparative analysis of STP6 and STP10 unravels molecular selectivity in sugar transport proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

João Victor GomesDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4652-0488
Shivinder Singh-BhaganiaDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0009-0001-6932-3903
Matthew CenciDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8696-1379
Carlos Chacon CordonDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4091-075X
Manjodh SinghDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0009-0000-1566-1790
Joel A ButterwickDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA. joel.butterwick@yale.edu.ORCID 0000-0002-5631-7774
Yale University · US

Funding

Understanding how membrane composition directs membrane protein structure and functionRM1GM149406 · NIGMS · YALE UNIVERSITY · PI Joel Adam Butterwick, KATHRYN M FERGUSON · 2023 to 2026
$8.4M
NIGMS NIH HHS RM1 GM149406
6 · The paper itself

Abstract

Animals crave sugars because of their energy potential and the pleasurable sensation of tasting sweetness. Yet all sugars are not metabolically equivalent, requiring mechanisms to detect and differentiate between chemically similar sweet substances. Insects use a family of ionotropic gustatory receptors to discriminate sugars

Indexed as

BombyxInsect ProteinsReceptors, G-Protein-CoupledSugarsTasteAllosteric RegulationAnimalsBinding SitesCryoelectron MicroscopyFructoseLigandsModels, MolecularMolecular Docking SimulationProtein BindingSorboseSubstrate SpecificityFructoseInsect ProteinsLigandsReceptors, G-Protein-CoupledSorboseSugarstaste receptors, type 1

Identifiers

PMID38447670
PMCPMC11062906
OpenAlexW4392504618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.