Evidence map›Paper›PMID 38447639›Full record

GuidelineChest2024

Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines.

Jeannie Callum, Nikolaos J Skubas, Aarti Bathla, Homa Keshavarz, Edward G Clark, Bram Rochwerg, Dean Fergusson, Sesmu Arbous, Seth R Bauer, Louise China and 14 more

Open access · bronzeAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Chest, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 6 pooled it
24.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 6 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Review
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. C-reactive Protein-to-albumin Ratio (CAR) in Polytrauma-Early Warning or Marker of Disease Evolution?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026
    Article
  18. Albumin in neonates: use it or lose it.Pediatric research · 2026
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 19 institutions in 5 countries.

Jeannie CallumDepartment of Pathology and Molecular Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, ON, Canada. Electronic address: jlc17@queensu.ca.
Nikolaos J SkubasDepartment of Cardiothoracic Anesthesiology, Anesthesiology Institute, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
Aarti BathlaCanadian Blood Services, Ottawa, ON, Canada.
Homa KeshavarzCanadian Blood Services, Ottawa, ON, Canada.
Edward G ClarkDivision of Nephrology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Bram RochwergDepartment of Medicine and Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Dean FergussonDepartment of Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Sesmu ArbousDepartment of Critical Care, Leiden University Medical Center, Leiden, The Netherlands.
Seth R BauerDepartment of Pharmacy, Cleveland Clinic, Cleveland, OH.
Louise ChinaDepartment of Hepatology and Institute for Liver and Digestive Health, The Royal Free NHS Trust and University College London, London, England.
Mark FungDepartment of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.
Rachel JugUniversity of Cincinnati College of Medicine, Cincinnati, OH.
Michael NeillPatient representative.
Cary PaineDivision of Nephrology, Department of Medicine, University of Washington, Seattle, WA.
Katerina PavenskiDepartment of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, Toronto, ON, Canada.
Prakesh S ShahInstitute of Health Policy, Management, and Evaluation, Mount Sinai Hospital, Toronto, ON, Canada; Department of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
Susan RobinsonDepartment of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, England.
Hua ShanDepartment of Pathology, Stanford University School of Medicine, Palo Alto, CA.
Zbigniew M SzczepiorkowskiDepartment of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Thierry ThevenotService d'Hépatologie, Centre Hospitalier Régional et Universitaire de Besançon, Besançon, France.
Bovey WuDepartment of Internal Medicine, Graduate Medical Education, Loma Linda University, Loma Linda, CA.
Simon StanworthNHS Blood and Transplant, Oxford, England; Radcliffe Department of Medicine, University of Oxford, Oxford, England; John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, England.
Nadine ShehataDepartment of Medicine, University of Toronto, Mount Sinai Hospital, Toronto, ON, Canada; Transfusion Medicine Laboratory, Mount Sinai Hospital, Toronto, ON, Canada.
International Collaboration for Transfusion Medicine Guidelines Intravenous Albumin Guideline Group
Mount Sinai Hospital · CACanadian Blood Services · CADartmouth–Hitchcock Medical Center · USGuy's and St Thomas' NHS Foundation Trust · GBJohn Radcliffe Hospital · GBQueen's University · CAUniversity of Cincinnati Medical Center · USUniversity of Ottawa · CAUniversity of Vermont Medical Center · USCentre Hospitalier Universitaire de Besançon · FRCleveland Clinic · USCleveland Clinic Lerner College of Medicine · USHamilton Health Sciences · CALeiden University Medical Center · NLLoma Linda University Medical Center · USOttawa Hospital · CARoyal Free London NHS Foundation Trust · GBStanford University · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlbumin is used commonly across a wide range of clinical settings to improve hemodynamics, to facilitate fluid removal, and to manage complications of cirrhosis. The International Collaboration for Transfusion Medicine Guidelines developed guidelines for the use of albumin in patients requiring critical care, undergoing cardiovascular surgery, undergoing kidney replacement therapy, or experiencing complications of cirrhosis. STUDY DESIGN AND

methodsCochairs oversaw the guideline development process and the panel included researchers, clinicians, methodologists, and a patient representative. The evidence informing this guideline arises from a systematic review of randomized clinical trials and systematic reviews, in which multiple databases were searched (inception through November 23, 2022). The panel reviewed the data and formulated the guideline recommendations using Grading of Recommendations Assessment, Development, and Evaluation methodology. The guidelines were revised after public consultation.

resultsThe panel made 14 recommendations on albumin use in adult critical care (three recommendations), pediatric critical care (one recommendation), neonatal critical care (two recommendations), cardiovascular surgery (two recommendations), kidney replacement therapy (one recommendation), and complications of cirrhosis (five recommendations). Of the 14 recommendations, two recommendations had moderate certainty of evidence, five recommendations had low certainty of evidence, and seven recommendations had very low certainty of evidence. Two of the 14 recommendations suggested conditional use of albumin for patients with cirrhosis undergoing large-volume paracentesis or with spontaneous bacterial peritonitis. Twelve of 14 recommendations did not suggest albumin use in a wide variety of clinical situations where albumin commonly is transfused.

interpretationCurrently, few evidence-based indications support the routine use of albumin in clinical practice to improve patient outcomes. These guidelines provide clinicians with actionable recommendations on the use of albumin.

Indexed as

AlbuminsAdministration, IntravenousCritical CareHumansLiver CirrhosisRenal Replacement TherapyTransfusion MedicineAlbuminsguidelineintensive careintravenous albuminkidney replacement therapyliver diseasesepsis

Identifiers

PMID38447639
PMCPMC11317816
OpenAlexW4392380532

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.