ArticleNeuron2024
Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit in visual cortex.
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Intrinsic timing, not temporal prediction, underlies ramping dynamics in visual and parietal cortex during passive behavior.Science advances · 2026Article
- Disinhibitory signaling enables flexible coding of top-down information in cortical networks.PLoS biology · 2026Article
- Targeting notch signaling to restore neural development and behavior in mouse models of ASD.Nature communications · 2026Article
- Article
- Learning-dependent cholinergic plasticity reconfigures cortical circuit dynamics.bioRxiv : the preprint server for biology · 2025Article
- Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications.Journal of neurochemistry · 2025Review
- Map of spiking activity underlying change detection in the mouse visual system.bioRxiv : the preprint server for biology · 2025Article
- Selective engagement of prefrontal VIP neurons in reversal learning.Science advances · 2025Article
- Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Bilateral integration in somatosensory cortex is controlled by behavioral relevance.Nature neuroscience · 2025Article
- Reveal the mechanism of brain function with fluorescence microscopy at single-cell resolution: from neural decoding to encoding.Journal of neuroengineering and rehabilitation · 2025Review
- Diversity of omission responses to visual images across brain-wide regions.Science advances · 2025Article
- Deciphering neuronal variability across states reveals dynamic sensory encoding.Nature communications · 2025Article
- Advances in two-photon imaging for monitoring neural activity in behaving mice.Frontiers in neuroscience · 2025Review
- Article
- Basolateral amygdala oscillations enable fear learning in a biophysical model.bioRxiv : the preprint server for biology · 2024Article
- Coordinated changes in a cortical circuit sculpt effects of novelty on neural dynamics.Cell reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
In complex environments, animals can adopt diverse strategies to find rewards. How distinct strategies differentially engage brain circuits is not well understood. Here, we investigate this question, focusing on the cortical Vip-Sst disinhibitory circuit between vasoactive intestinal peptide-postive (Vip) interneurons and somatostatin-positive (Sst) interneurons. We characterize the behavioral strategies used by mice during a visual change detection task. Using a dynamic logistic regression model, we find that individual mice use mixtures of a visual comparison strategy and a statistical timing strategy. Separately, mice also have periods of task engagement and disengagement. Two-photon calcium imaging shows large strategy-dependent differences in neural activity in excitatory, Sst inhibitory, and Vip inhibitory cells in response to both image changes and image omissions. In contrast, task engagement has limited effects on neural population activity. We find that the diversity of neural correlates of strategy can be understood parsimoniously as the increased activation of the Vip-Sst disinhibitory circuit during the visual comparison strategy, which facilitates task-appropriate responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.