ArticleNeuron2024
Excitability mediates allocation of pre-configured ensembles to a hippocampal engram supporting contextual conditioned threat in mice.
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Basolateral amygdala neurons await oscillatory recruitment into valence-relevant ensembles.bioRxiv : the preprint server for biology · 2026Article
- Basolateral amygdala neurons await oscillatory recruitment into valence-relevant ensembles.Research square · 2026Article
- The intrinsic excitability of and autophagy protein expression levels in dentate gyrus ensembles regulate fear generalization.Neural regeneration research · 2026Article
- Microglia-dependent regulation of fear memory extinction.Nature neuroscience · 2026Article
- CA1 Engram Cell Dynamics Before and After Learning.bioRxiv : the preprint server for biology · 2026Article
- The prefrontal cortex controls memory organization in the hippocampus.Nature neuroscience · 2026Article
- Deconstruction of a memory engram reveals distinct ensembles recruited at learning.Nature neuroscience · 2026Article
- Developmental emergence of sparse and structured synaptic connectivity in the hippocampal CA3 memory circuit.Nature communications · 2026Article
- Perillaldehyde reduces mitochondrial oxidative stress damage by regulating KCNT2/NR1D1 protein activity in vascular dementia rats.Molecular biology reports · 2026Article
- Activation of Kv7.3 channels in mPFC engram neurons suppresses methamphetamine memory retrieval by reducing excitability and glutamate release in the mPFC-NAc circuit.Cellular and molecular life sciences : CMLS · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Distinct CA1 inputs support shifts in neural dimensionality and memory resolution.bioRxiv : the preprint server for biology · 2026Article
- Neural substrate of conditioned stimulus for associative learning in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Memory engram synapse 3D macromolecular architecture visualized by cryoCLEM-guided cryoET.Structure (London, England : 1993) · 2026Article
- Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons.Frontiers in aging neuroscience · 2026Review
- Growth hormone is required for hippocampal engram cell maturation.Science advances · 2025Article
- Early changes in the properties of CA3 engram cells explored with a novel viral tool in mice.eLife · 2025Article
- Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans.Nature neuroscience · 2025Review
- Neurobiological and Existential Profiles in Posttraumatic Stress Disorder: The Role of Serotonin, Cortisol, Noradrenaline, and IL-12 Across Chronicity and Age.International journal of molecular sciences · 2025Article
- Adverse gestational environment configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety.Cell reports · 2025Article
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9 authors.
Funding
Abstract
Little is understood about how engrams, sparse groups of neurons that store memories, are formed endogenously. Here, we combined calcium imaging, activity tagging, and optogenetics to examine the role of neuronal excitability and pre-existing functional connectivity on the allocation of mouse cornu ammonis area 1 (CA1) hippocampal neurons to an engram ensemble supporting a contextual threat memory. Engram neurons (high activity during recall or TRAP2-tagged during training) were more active than non-engram neurons 3 h (but not 24 h to 5 days) before training. Consistent with this, optogenetically inhibiting scFLARE2-tagged neurons active in homecage 3 h, but not 24 h, before conditioning disrupted memory retrieval, indicating that neurons with higher pre-training excitability were allocated to the engram. We also observed stable pre-configured functionally connected sub-ensembles of neurons whose activity cycled over days. Sub-ensembles that were more active before training were allocated to the engram, and their functional connectivity increased at training. Therefore, both neuronal excitability and pre-configured functional connectivity mediate allocation to an engram ensemble.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.