ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Urolithin A Hijacks ERK1/2-ULK1 Cascade to Improve CD8
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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
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Who cites it
27 citing papers in PubMed, 22 citations in OpenAlex.
- The impact of gut microbiota and metabolite-driven immune cell spatiotemporal dynamics on tumors.Gut microbes · 2026Review
- Phosphorylation of OTUB1 promotes autophagy initiation under starvation.Nature communications · 2026Article
- Discovery of a novel dual-target modulator of ULK1 and ERK1/2 that suppresses triple-negative breast cancer progression and metastasis via the Exo70/Cav-1/MMPs axis.Acta pharmacologica Sinica · 2026Article
- Functional Food-Derived Urolithins: Molecular Mechanisms, Health Effects, and Interactomics with Proteins and Extracellular Vesicles.Molecules (Basel, Switzerland) · 2026Review
- Plantaricin BM-1 enhances anti-colorectal cancer effects by inhibiting CD8+ cytotoxic T cell apoptosis via the ERK/AP1/Bim signaling pathway.Frontiers in immunology · 2026Article
- Gut metabolites: key factors in the cross-talk between the gut microbiota and tumor immunotherapy.Frontiers in immunology · 2026Review
- Mitophagy in the pathogenesis and management of disease.Cell research · 2026Review
- Interplay of gut microbiota, immune cells and natural products in reshaping cancer immunotherapy.Frontiers in microbiology · 2026Review
- The gut microbiota in cancer immunity and immunotherapy.Cellular & molecular immunology · 2025Review
- NIR Driven Pd/Cerium Oxide Nano-Heterojunction for Enhanced Salvaging Sepsis Induced Acute Liver Injury via Reprogramming Redox Homeostasis in Synergy with Inducing Autophagy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis.Biology · 2025Article
- Recent advances and challenges of cellular immunotherapies in lung cancer treatment.Experimental hematology & oncology · 2025Review
- Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges.Biomedicines · 2025Review
- Review
- CYB5A promotes osteogenic differentiation of MC3T3-E1 cells through autophagy mediated by the AKT/mTOR/ULK1 signaling pathway.Scientific reports · 2025Article
- Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity.Cell reports. Medicine · 2025Article
- Urolithin A Enhances Tight Junction Protein Expression in Endothelial Cells Cultured In Vitro via Pink1-Parkin-Mediated Mitophagy in Irradiated Astrocytes.Journal of molecular neuroscience : MN · 2025Article
- Gut microbiota-derived metabolites in immunomodulation and gastrointestinal cancer immunotherapy.Frontiers in immunology · 2025Review
- Tumor microenvironment-driven resistance to immunotherapy in non-small cell lung cancer: strategies for Cold-to-Hot tumor transformation.Cancer drug resistance (Alhambra, Calif.) · 2025Review
- Coumarins in the tumor-immune application: from molecular mechanisms to therapeutic innovations.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
23 authors at 5 institutions in 1 country.
Shuaiya MaKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Qi WuGI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, P. R. China.
Wenxian WuKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.ORCID 0000-0003-4059-5945
Ye TianKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Jie ZhangAdvanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Chaojia ChenKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Xue ShengKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Fangcheng ZhaoKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Lu DingKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Taixia WangCentral Laboratory, Tongji University School of Medicine, Tongji University, Shanghai, 200072, P. R. China.
Laixi ZhaoKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Yuying XieGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Disease, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, P. R. China.
Yongxiang WangGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Disease, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, P. R. China.
Xuetian YueKey Laboratory for Experimental Teratology of Ministry of Education and Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Zhuanchang WuKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Jian WeiDepartment of Physiology, School of Basic Medical Sciences, Shandong University, Jinan, 250012, P. R. China.
Kun ZhangCentral Laboratory, Tongji University School of Medicine, Tongji University, Shanghai, 200072, P. R. China.
Xiaohong LiangKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Lifen GaoKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.
Hongyan WangState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, P. R. China.
Guihua WangGI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, P. R. China.
Chunyang LiKey Laboratory for Experimental Teratology of Ministry of Education and Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.ORCID 0000-0002-5798-2274
Chunhong MaKey Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P. R. China.ORCID 0000-0002-8121-4718
Shandong University · CNGuangdong Medical College · CNHuazhong University of Science and Technology Hospital · CNTongji University · CNCenter for Excellence in Molecular Cell Science · CN
Funding
Cutting Edge Development Fund of Advanced Medical Research Institute GYY2023QY01Guangdong Basic and Applied Basic Research Foundation 2021A1515110965Major Basic Research Project of Shandong Natural Science Foundation ZR2020ZD12National key R&D program 2021YFC2300603；2022YFA1105303National Natural Science Foundation of China 31600714National Natural Science Foundation of China 32270800National Natural Science Foundation of China 81830017National Natural Science Foundation of China 81922053National Natural Science Foundation of China 82230056National Natural Science Foundation of China 82271878National Natural Science Foundation of China 82330084National Postdoctoral Program for Innovative Talents BX201700147Shandong Excellent Young Scientists Fund Program (Overseas) 2022HWYQ-028Shandong Provincial Natural Science Foundation ZR2022MC012Taishan Scholarship tspd20181201Young Elite Scientist Sponsorship Program YESS20160077Young Scholars Program of Shandong University
Abstract
According to the latest evidence, the microbial metabolite Urolithin A (UA), known for its role in promoting cellular health, modulates CD8
Indexed as
Autophagy-Related Protein-1 HomologCD8-Positive T-LymphocytesCoumarinsAnimalsAutophagyDisease Models, AnimalHumansMAP Kinase Signaling SystemMiceMice, Inbred C57BLNeoplasms3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-oneAutophagy-Related Protein-1 HomologCoumarinsUlk1 protein, mouseautophagyCAR T cellsCD8+ cytotoxic T cellsERK1/2Urolithin A (UA)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.