Evidence map›Paper›PMID 38447043›Full record

ArticleAIDS care2024

High mortality in adolescents and young adults with perinatally-acquired HIV in Thailand during the transition to adulthood.

Pradthana Ounchanum, Linda Aurpibul, Sirinya Teeraananchai, Pagakrong Lumbiganon, Wipaporn Natalie Songtaweesin, Tavitiya Sudjaritruk, Kulkanya Chokephaibulkit, Supattra Rungmaitree, Pope Kosalaraksa, Tulathip Suwanlerk and 3 more

Abstract read
In one paragraph

Article in AIDS care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. "AIDS care · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pradthana OunchanumDepartment of Pediatrics, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand.
Linda AurpibulResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.ORCID 0000-0003-0246-8187
Sirinya TeeraananchaiDepartment of Statistics, Faculty of Science, Kasetsart University, Bangkok, Thailand.
Pagakrong LumbiganonDepartment of Pediatrics, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kean, Thailand.
Wipaporn Natalie SongtaweesinDepartment of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Tavitiya SudjaritrukDepartment of Pediatrics and Clinical and Molecular Epidemiology of Emerging and Re-emerging Infectious Diseases Research Cluster, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Kulkanya ChokephaibulkitSiriraj Institute of Clinical Research and Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Supattra RungmaitreeDepartment of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Pope KosalaraksaDepartment of Pediatrics, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kean, Thailand.
Tulathip SuwanlerkTREAT Asia/amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
Jeremy L RossTREAT Asia/amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
Annette H SohnTREAT Asia/amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
Thanyawee PuthanakitDepartment of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
Capacity development for HIV and mental health research in Asia (CHIMERA)D43TW011302 · FIC · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN, MILTON L WAINBERG · 2019 to 2026
$2.1M
FIC NIH HHS D43 TW011302NIAID NIH HHS U01 AI069907
6 · The paper itself

Abstract

Transitioning from pediatric to adult care remains a challenge for adolescents and young adults with perinatally-acquired HIV (AYA-PHIV). We assessed treatment outcomes and mortality among Thai AYA-PHIV. The study included AYA-PHIV who reached age 18-24 years who started antiretroviral treatment during childhood at five pediatric HIV clinics across Thailand. From November 2020-July 2021, data were gathered from a cohort database, medical records, and the Thai National AIDS Program. Of 811 eligible AYA-PHIV, 93% were alive; median age 22.3 years (IQR 20.6-23.7), treatment duration 16.1 years (IQR 13.4-18.0). Current HIV care was provided in adults (71%) and pediatric clinics (29%). Treatment regimens included non-nucleoside reverse transcriptase inhibitors (55%), protease inhibitors (36%), and integrase inhibitors (8%); 78% had HIV RNA <200 copies/ml. Of the 7.0% who died, median age at death was 20.8 years (IQR 20.6-22.1); 88% were AIDS-related death. Mortality after age 18 was 1.76 per 100-person years (95% confidence interval 1.36-2.28). Those with CD4 <200 cell/mm

Indexed as

HIV InfectionsAdolescentAdultAnti-HIV AgentsFemaleHumansInfectious Disease Transmission, VerticalMaleThailandTransition to Adult CareYoung AdultAnti-HIV AgentsadolescentsMortalityperinatally acquired HIVSDG 3: Good health and well-beingThailandyoung adults

Identifiers

PMID38447043
PMCPMC11518584

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.