Evidence map›Paper›PMID 38446898›Full record

ArticleScience advances2024

Childhood adverse life events and skeletal muscle mitochondrial function.

Kate A Duchowny, David J Marcinek, Theresa Mau, L Grisell Diaz-Ramierz, Li-Yung Lui, Frederico G S Toledo, Peggy M Cawthon, Russell T Hepple, Philip A Kramer, Anne B Newman and 4 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Lifetime adversity exposure, mood symptoms, and immune mitochondrial bioenergetics.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
  5. Article
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  7. Article
  8. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Kate A DuchownyInstitute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9771-8454
David J MarcinekDepartment of Radiology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5187-2149
Theresa MauCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.ORCID 0000-0003-4278-6438
L Grisell Diaz-RamierzDivision of Geriatrics, Department of Medicine, UCSF School of Medicine, San Francisco, CA, USA.ORCID 0000-0003-1621-9309
Li-Yung LuiCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Frederico G S ToledoDepartment of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, USA.
Peggy M CawthonCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.ORCID 0000-0003-4938-9478
Russell T HeppleDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-3640-486X
Philip A KramerDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0001-6554-631X
Anne B NewmanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-0106-1150
Stephen B KritchevskyDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.ORCID 0000-0001-8808-260X
Paul M CoenAdventHealth, Translational Research Institute, Orlando, FL, USA.ORCID 0000-0002-2805-2115
Anthony J A MolinaDepartment of Medicine-Division of Geriatrics, Gerontology, and Palliative Care, University of California San Diego School of Medicine, La Jolla, CA, USA.ORCID 0000-0002-5786-4622
University of California, San Francisco · USUniversity of Pittsburgh · USWake Forest University · USCalifornia Pacific Medical Center · USTranslational Research Institute for Metabolism and Diabetes · USUniversity of California San Diego · USUniversity of Florida · USUniversity of Michigan · USUniversity of Washington · US

Funding

Study of Muscle, Mobility and Aging: SOMMA2R01AG059416 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STEVEN RON CUMMINGS, Peggy Mannen Cawthon · 2018 to 2026
$70.3M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LEON LENCHIK · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Study of Muscle, Mobility and Aging: SOMMA2R56AG059416 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, GOODPASTER, BRET H · 2023 to 2023
$3.1M
Examining the role of the neighborhood environment on muscle function in older adultsR00AG066846 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUCHOWNY, CATHERINE · 2023 to 2025
$742k
NCATS NIH HHS UL1 TR001420NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS R00 AG066846NIA NIH HHS R01 AG059416NIA NIH HHS R56 AG059416
6 · The paper itself

Abstract

Social stress experienced in childhood is associated with adverse health later in life. Mitochondrial function has been implicated as a mechanism for how stressful life events "get under the skin" to influence physical well-being. Using data from the Study of Muscle, Mobility, and Aging (

Indexed as

Muscle, SkeletalMusculoskeletal Physiological PhenomenaAdenosine TriphosphateAgedAgingFemaleHumansMaleMitochondriaAdenosine Triphosphate

Identifiers

PMID38446898
PMCPMC10917337
OpenAlexW4392528357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.