ArticleScience advances2024
Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8
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Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Oxidative Stress, Post-Translational Modifications, and Type 1 Diabetes Pathogenesis.Immunological reviews · 2026Review
- Coxsackievirus B escapes antiviral CD8Science advances · 2026Article
- The Downregulation of Type 1 Diabetes Susceptibility Gene PGM1 Induces Metabolic Imbalance and Stress in Pancreatic β-Cells.Diabetes · 2026Article
- PTPN2 deficiency amplifies inflammatory signalling and impairs functional maturation of human stem cell-derived islets.Stem cell research & therapy · 2026Article
- Stress-driven remodeling of antigen presentation and chemokine signaling in pancreatic β-cells: implications for type 1 diabetes.Frontiers in immunology · 2026Review
- 3D Bioprinting Strategies in Autoimmune Disease Models.International journal of molecular sciences · 2025Review
- mRNA vaccine expressing enterovirus D68 virus-like particles induces potent neutralizing antibodies and protects against infection.Molecular therapy. Nucleic acids · 2025Article
- Mimicry in the Bite: Shared Sequences BetweenProteomes · 2025Article
- Coxsackievirus B infection invokes unique cell-type-specific responses in primary human pancreatic islets.Cell reports · 2025Article
- The Role of Viral Infections in Acute Kidney Injury and Mesenchymal Stem Cell-Based Therapy.Stem cell reviews and reports · 2025Review
- Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells.Nature communications · 2025Article
- The perfect storm: unraveling the interplay of genetic predisposition and viral triggers in type 1 diabetes pathogenesis.Frontiers in endocrinology · 2025Review
- Viral manipulation of the HLA class I antigen processing and presentation pathway.Frontiers in immunology · 2025Review
- Article
- Article
- Untangling the genetics of beta cell dysfunction and death in type 1 diabetes.Molecular metabolism · 2024Review
- Enteroviruses: epidemic potential, challenges and opportunities with vaccines.Journal of biomedical science · 2024Review
- Immunological and virological triggers of type 1 diabetes: insights and implications.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
35 authors at 13 institutions in 7 countries.
Federica VecchioUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0003-4607-8818
Alexia CarréUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0001-8144-7194
Daniil KorenkovUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0001-8321-778X
Zhicheng ZhouUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0001-9137-7951
Paola ApaolazaInstitute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.ORCID 0000-0002-7550-054X
Soile TuomelaCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Orlando Burgos-MoralesUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Isaac SnowhiteDiabetes Research Institute, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0009-0008-9387-0318
Javier Perez-HernandezUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0001-9712-2917
Barbara BrandaoUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0009-0008-0128-0100
Georgia AfonsoUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0003-3759-7317
Clémentine HalliezUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0002-5683-515X
John KaddisDepartment of Diabetes Immunology, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID 0000-0002-6752-7670
Sally C KentDiabetes Center of Excellence, Department of Medicine, University of Massachusetts Medical Chan School, Worcester, MA, USA.
Maki NakayamaBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-0009-3687
Sarah J RichardsonIslet Biology Exeter (IBEx), Exeter Centre of Excellence for Diabetes Research (EXCEED), Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.ORCID 0000-0002-1160-6062
Joelle VinhESPCI Paris, PSL University, Spectrométrie de Masse Biologique et Protéomique, CNRS UMR8249, Paris, France.ORCID 0000-0001-7184-2668
Yann VerdierESPCI Paris, PSL University, Spectrométrie de Masse Biologique et Protéomique, CNRS UMR8249, Paris, France.ORCID 0000-0002-3319-0053
Jutta LaihoFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0002-5443-4651
Raphael ScharfmannUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Michele SolimenaGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Zuzana MarinicovaGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.ORCID 0009-0008-6416-8247
Elise BismuthAssistance Publique Hôpitaux de Paris, Service d'Endocrinologie Pédiatrique, Robert Debré Hospital, Paris, France.
Nadine LucidarmeAssistance Publique Hôpitaux de Paris, Service de Pédiatrie, Jean Verdier Hospital, Bondy, France.
Janine SanchezDepartment of Pediatrics, Division of Pediatric Endocrinology, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0000-0003-3790-6140
Carmen BustamanteDepartment of Pediatrics, Division of Pediatric Endocrinology, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA.
Patricia GomezDepartment of Pediatrics, Division of Pediatric Endocrinology, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0000-0002-3211-7647
Soren BuusDepartment of Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8363-1999
nPOD-Virus Working Group
Sylvaine YouUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0002-1578-5205
Alberto PuglieseDiabetes Research Institute, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0000-0002-7211-0319
Heikki HyotyFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0003-0370-4145
Teresa Rodriguez-CalvoInstitute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.ORCID 0000-0003-1531-8583
Malin Flodstrom-TullbergCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.ORCID 0000-0003-2685-2052
Roberto MalloneUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0002-9846-8861
Centre National de la Recherche Scientifique · FRUniversity of Miami · USAssistance Publique – Hôpitaux de Paris · FRDeutsches Diabetes-Zentrum e.V. · DEKarolinska University Hospital · SECity of Hope · USHelmholtz Zentrum München · DETampere University · FITampere University of Applied Sciences · FIUniversity of Colorado Denver · USUniversity of Copenhagen · DKUniversity of Exeter · GBUniversity of Massachusetts Chan Medical School · US
Funding
Renewal of the Human Islet Research Enhancement Center (HIREC) for the Type-1-Diabetes-Focused Human Islet Research Network (HIRN).U24DK104162 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI John S. Kaddis, Joyce Carol Niland · 2019 to 2026
$12.3MMultiple Autoantigens/Multiple Epitopes of Type 1DMR01DK032083 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MICHELS, AARON W · 1986 to 2025
$6.9MMolecular Dissection of Insulin Targeting in Anti-Islet AutoimmunityR01DK099317 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI AARON W MICHELS, Maki Nakayama · 2013 to 2026
$5.3MMedical Research Council MR/P010695/1NIDDK NIH HHS R01 DK032083NIDDK NIH HHS R01 DK099317NIDDK NIH HHS U24 DK104162
Abstract
Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β cell autoimmunity and type 1 diabetes. We investigated how CVB affects human β cells and anti-CVB T cell responses. β cells were efficiently infected by CVB in vitro, down-regulated human leukocyte antigen (HLA) class I, and presented few, selected HLA-bound viral peptides. Circulating CD8
Indexed as
Coxsackievirus InfectionsDiabetes Mellitus, Type 1Insulin-Secreting CellsAntibodiesAntiviral AgentsCD8-Positive T-LymphocytesEpitopesHumansPeptidesAntibodiesAntiviral AgentsEpitopesPeptides
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.