ArticleProceedings of the National Academy of Sciences of the United States of America2024
Blocking endogenous retinoic acid degradation induces oral tooth formation in zebrafish.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Loss, persistence and reversal of phenotypic traits.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury.Cell proliferation · 2026Article
- The metamorphic transition of the frog mouth: from tadpole keratinized mouthparts to adult teeth.Royal Society open science · 2025Article
- Challenging and redefining Dollo's law of evolution: re-appearance of lost structures.BMC ecology and evolution · 2025Review
- Experimental induction of supernumerary teeth in zebrafish: Oral teeth perhaps, dorsal teeth for sure.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Reply to Huysseune and Witten: Oral tooth bud formation in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
According to Dollo's Law of irreversibility in evolution, a lost structure is usually considered to be unable to reappear in evolution due to the accumulation over time of mutations in the genes required for its formation. Cypriniform fish are a classic model of evolutionary loss because, while they form fully operational teeth in the ventral posterior pharynx, unlike other teleosts, they do not possess oral teeth. Paleontological data show that Cypriniforms, a clade of teleost fish that includes the zebrafish, lost their oral teeth 50 to 100 Mya. In order to attempt to reverse oral tooth loss in zebrafish, we block the degradation of endogenous levels of retinoic acid (RA) using a specific inhibitor of the Cyp26 RA degrading enzymes. We demonstrate the inhibition of endogenous RA degradation is sufficient to restore oral tooth induction as marked by the re-appearance of expression of early dental mesenchyme and epithelium genes such as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.