ArticleProceedings of the National Academy of Sciences of the United States of America2024
Common modular architecture across diverse cortical areas in early development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Millimeter-scale selective amplification in the developing visual cortex.bioRxiv : the preprint server for biology · 2026Article
- Deriving functional network topology frombioRxiv : the preprint server for biology · 2026Article
- Iso-orientation bias of layer 2/3 connections unifies spontaneous, visually and optogenetically driven V1 dynamics.Nature communications · 2026Article
- Article
- Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Stereotyped Spatiotemporal Dynamics of Spontaneous Activity in Visual Cortex Prior to Eye Opening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Perceptual and semantic maps in individual humans share structural features that predict creative abilities.Communications psychology · 2025Article
- Expression of synaptic proteins and development of dendritic spines in fetal and postnatal neocortex of the pig, the European wild boar Sus scrofa.Brain structure & function · 2025Article
- Developmental maturation of millimeter-scale functional networks across brain areas.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- The developmental emergence of reliable cortical representations.Nature neuroscience · 2025Article
- Vascular Development of Fetal and Postnatal Neocortex of the Pig, the European Wild Boar Sus scrofa.The Journal of comparative neurology · 2024Article
- Developmental maturation of millimeter-scale functional networks across brain areas.bioRxiv : the preprint server for biology · 2024Article
- Self-organization of modular activity in immature cortical networks.Nature communications · 2024Article
- Common modular architecture across diverse cortical areas in early development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Face detection mechanisms: NatureFrontiers in neuroscience · 2024Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
In order to deal with a complex environment, animals form a diverse range of neural representations that vary across cortical areas, ranging from largely unimodal sensory input to higher-order representations of goals, outcomes, and motivation. The developmental origin of this diversity is currently unclear, as representations could arise through processes that are already area-specific from the earliest developmental stages or alternatively, they could emerge from an initially common functional organization shared across areas. Here, we use spontaneous activity recorded with two-photon and widefield calcium imaging to reveal the functional organization across the early developing cortex in ferrets, a species with a well-characterized columnar organization and modular structure of spontaneous activity in the visual cortex. We find that in animals 7 to 14 d prior to eye-opening and ear canal opening, spontaneous activity in both sensory areas (auditory and somatosensory cortex, A1 and S1, respectively), and association areas (posterior parietal and prefrontal cortex, PPC and PFC, respectively) showed an organized and modular structure that is highly similar to the organization in V1. In all cortical areas, this modular activity was distributed across the cortical surface, forming functional networks that exhibit millimeter-scale correlations. Moreover, this modular structure was evident in highly coherent spontaneous activity at the cellular level, with strong correlations among local populations of neurons apparent in all cortical areas examined. Together, our results demonstrate a common distributed and modular organization across the cortex during early development, suggesting that diverse cortical representations develop initially according to similar design principles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.