Evidence map›Paper›PMID 38446806›Full record

ArticlePloS one2024

Genomic characterization of SARS-CoV-2 in Guinea, West Africa.

Mamadou Saliou Sow, Josue Togo, Lacy M Simons, Souleymane Taran Diallo, Mohamed Lamine Magassouba, Mamadou Bhoye Keita, Anou Moise Somboro, Youssouf Coulibaly, Egon A Ozer, Judd F Hultquist and 4 more

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mamadou Saliou SowService de Maladie Infectieuse du Centre Hospitalier de Donka, Conakry, Guinée.
Josue TogoUniversity Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Lacy M SimonsDivision of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Souleymane Taran DialloService de Maladie Infectieuse du Centre Hospitalier de Donka, Conakry, Guinée.
Mohamed Lamine MagassoubaService de Maladie Infectieuse du Centre Hospitalier de Donka, Conakry, Guinée.
Mamadou Bhoye KeitaDépartement de laboratoire, Institut National de la Santé Publique, Conakry, Guinée.
Anou Moise SomboroUniversity Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Youssouf CoulibalyUniversity Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Egon A OzerDivision of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.ORCID 0000-0002-7131-3691
Judd F HultquistCenter for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, IL, United States of America.
Robert Leo MurphyInstitute for Global Health, Northwestern University, Chicago, IL, United States of America.
Almoustapha Issiaka MaigaUniversity Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Mamoudou MaigaInstitute for Global Health, Northwestern University, Chicago, IL, United States of America.
Ramon Lorenzo-RedondoDivision of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.ORCID 0000-0002-5462-9483

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
The Institute for Translational MedicineUL1TR002389 · NCATS · UNIVERSITY OF CHICAGO · PI Joshua J Jacobs, DAVID O MELTZER · 2017 to 2026
$71.6M
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Virology and Immunology Technology CoreP30AI117943 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Richard D'Aquila, Brian Mustanski · 2015 to 2026
$38.4M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUIS A. Nunes AMARAL · 2018 to 2026
$24.7M
HIV and Mycobacterial Disease in MaliD43TW010350 · FIC · UNIV OF SCIENCES, TECH & TECH OF BAMAKO · PI MAIGA, ALMOUSTAPHA ISSIAKA, MURPHY, ROBERT LEO · 2016 to 2025
$3.0M
Assessing the Risk of SARS-CoV-2 Remdesivir ResistanceR21AI163912 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HULTQUIST, JUDD F · 2021 to 2022
$440k
FIC NIH HHS D43 TW010350NCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1 TR002389NCI NIH HHS P30 CA060553NIAID NIH HHS P30 AI117943NIAID NIH HHS R21 AI163912NIAID NIH HHS U19 AI135964
6 · The paper itself

Abstract

SARS-CoV-2 has claimed several million lives since its emergence in late 2019. The ongoing evolution of the virus has resulted in the periodic emergence of new viral variants with distinct fitness advantages, including enhanced transmission and immune escape. While several SARS-CoV-2 variants of concern trace their origins back to the African continent-including Beta, Eta, and Omicron-most countries in Africa remain under-sampled in global genomic surveillance efforts. In an effort to begin filling these knowledge gaps, we conducted retrospective viral genomic surveillance in Guinea from October 2020 to August 2021. We found that SARS-CoV-2 clades 20A, 20B, and 20C dominated throughout 2020 until the coincident emergence of the Alpha and Eta variants of concern in January 2021. The Alpha variant remained dominant throughout early 2021 until the arrival of the Delta variant in July. Surprisingly, despite the small sample size of our study, we also found the persistence of the early SARS-CoV-2 clade 19B as late as April 2021. Together, these data help fill in our understanding of the SARS-CoV-2 population dynamics in West Africa early in the COVID-19 pandemic.

Indexed as

COVID-19SARS-CoV-2Africa, WesternGenomicsGuineaHumansPandemicsRetrospective Studies

Identifiers

PMID38446806
PMCPMC10917296

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.