Evidence map›Paper›PMID 38446639›Full record

ArticleMolecular biology of the cell2024

Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function.

Melissa J Mann, Chris Melendez-Suchi, Hannah E Vorndran, Maria Sukhoplyasova, Ashley R Flory, Mary Carson Irvine, Anuradha R Iyer, Christopher J Guerriero, Jeffrey L Brodsky, Linda M Hendershot and 1 more

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Foods (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Melissa J MannDepartment of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 30105.
Chris Melendez-SuchiDepartment of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 30105.
Hannah E VorndranDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260.
Maria SukhoplyasovaDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260.
Ashley R FloryDepartment of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 30105.
Mary Carson IrvineDepartment of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 30105.
Anuradha R IyerDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260.
Christopher J GuerrieroDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260.
Jeffrey L BrodskyDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260.ORCID 0000-0002-6984-8486
Linda M HendershotDepartment of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 30105.
Teresa M BuckDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260.ORCID 0000-0002-9013-9756
University of Pittsburgh · USSt. Jude Children's Research Hospital · US

Funding

Resource Development CoreU54DK137329 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerard L Apodaca · 2023 to 2026
$4.8M
Modulating Hsp70-dependent proteostasis in Alzheimer's DiseaseR35GM131732 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JEFFREY L. BRODSKY · 2019 to 2026
$3.4M
NIDDK NIH HHS U54 DK137329NIGMS NIH HHS R35 GM131732
6 · The paper itself

Abstract

GRP170 (

Indexed as

Embryonic DevelopmentEndoplasmic Reticulum Chaperone BiPHSP70 Heat-Shock ProteinsAnimalsEndoplasmic ReticulumFibroblastsHumansMiceMolecular ChaperonesEndoplasmic Reticulum Chaperone BiPglucose-regulated protein 170HSP70 Heat-Shock ProteinsMolecular Chaperonesoxygen-regulated proteins

Identifiers

PMID38446639
PMCPMC11064666
OpenAlexW4392504321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.