Evidence map›Paper›PMID 38446637›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2024

In utero exposure to maternal diabetes exacerbates dietary sodium intake-induced endothelial dysfunction by activating cyclooxygenase 2-derived prostanoids.

Rafael M Costa, Débora Malta Cerqueira, Lydia Francis, Ariane Bruder-Nascimento, Juliano V Alves, Sunder Sims-Lucas, Jacqueline Ho, Thiago Bruder-Nascimento

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Rafael M CostaDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Débora Malta CerqueiraDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0001-9773-4606
Lydia FrancisDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Ariane Bruder-NascimentoDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Juliano V AlvesDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Sunder Sims-LucasDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-1908-4809
Jacqueline HoDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0001-7115-1381
Thiago Bruder-NascimentoDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0001-5671-318X
University of Pittsburgh · US

Funding

The role of Sirtuin 5 in acute kidney injuryR01DK121758 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIMS-LUCAS, SUNDER · 2020 to 2024
$2.3M
Endothelial miR-17~92 protects against acute kidney injuryR01DK125015 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HO, JACQUELINE, SIMS-LUCAS, SUNDER · 2020 to 2023
$1.5M
Regulation of tubulointerstitial crosstalk by microRNAs in renal fibrosisR01DK137410 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HO, JACQUELINE · 2023 to 2025
$936k
Leptin, a therapeutic avenue for the treatment of vascular disease, focus on congenital and antiretroviral therapy-associated lipodystrophiesR00HL140139 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRUDER, THIAGO · 2019 to 2021
$733k
The University of Pittsburgh Summer Research Internship Program kidney workshop (SRIP-Kid)R25DK119180 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACQUELINE HO, Sunder Sims-Lucas · 2021 to 2026
$648k
The Children’s Hospital of Pittsburgh -Cardiology, Hematology and Pulmonology Summer Research Internship Program (CHP2-SRIP)R25HL158295 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS, SIMS-LUCAS, SUNDER · 2021 to 2025
$633k
NHLBI NIH HHS R00 HL140139NHLBI NIH HHS R25 HL158295NIDDK NIH HHS R01 DK121758NIDDK NIH HHS R01 DK125015NIDDK NIH HHS R01 DK137410NIDDK NIH HHS R25 DK119180
6 · The paper itself

Abstract

Prenatal exposure to maternal diabetes has been recognized as a significant cardiovascular risk factor, increasing the susceptibility to the emergence of conditions such as high blood pressure, atherosclerosis, and heart disease in later stages of life. However, it is unclear if offspring exposed to diabetes in utero have worse vascular outcomes on a high-salt (HS) diet. To test the hypothesis that in utero exposure to maternal diabetes predisposes to HS-induced vascular dysfunction, we treated adult male wild-type offspring (DM_Exp, 6 mo old) of diabetic

Indexed as

Diabetes, GestationalEndothelium, VascularPrenatal Exposure Delayed EffectsProstaglandinsAnimalsCyclooxygenase 2FemaleInflammationMicePregnancySodium Chloride, DietaryCyclooxygenase 2ProstaglandinsSodium Chloride, Dietarydiabetesendotheliumsaltvascular function

Identifiers

PMID38446637
PMCPMC11376489
OpenAlexW4392520282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.