Evidence map›Paper›PMID 38446373›Full record

ArticleMolecular diversity2025

Rhodanine-benzamides as potential hits for α-amylase enzyme inhibitors and radical (DPPH and ABTS) scavengers.

Samuel Attah Egu, Irfan Ali, Khalid Mohammed Khan, Sridevi Chigurupati, Urooj Qureshi, Uzma Salar, Zaheer Ul-Haq, Suliman A Almahmoud, Shatha Ghazi Felemban, Mohsin Ali and 1 more

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Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Samuel Attah EguDepartment of Pure and Industrial Chemistry, Kogi State University, Anyigba, Kogi State, Nigeria.
Irfan AliInternational Center for Chemical and Biological Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Khalid Mohammed KhanInternational Center for Chemical and Biological Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan. khalid.khan@iccs.edu.
Sridevi ChigurupatiDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, 52571, Kingdom of Saudi Arabia.
Urooj QureshiDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Uzma SalarDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Zaheer Ul-HaqDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Suliman A AlmahmoudDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, 52571, Kingdom of Saudi Arabia.
Shatha Ghazi FelembanDepartment of Medical Laboratory Science, Fakeeh College for Medical Sciences, Jeddah, 21461, Kingdom of Saudi Arabia.
Mohsin AliDepartment of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Muhammad TahaDepartment of Clinical Pharmacy, Institute for Research and Medical Consultations [IRMC], Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Kingdom of Saudi Arabia.

Funding

Pakistan Academy of Sciences PAS Project No. 111
6 · The paper itself

Abstract

A series of 3-substituted and 3,5-disubstituted rhodanine-based derivatives were synthesized from 3-aminorhodanine and examined for α-amylase inhibitory, DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activities in vitro. These derivatives displayed significant α-amylase inhibitory potential with IC

Indexed as

alpha-AmylasesBenzamidesEnzyme InhibitorsFree Radical ScavengersRhodanineBenzothiazolesBiphenyl CompoundsMolecular Docking SimulationPicratesStructure-Activity RelationshipSulfonic Acids1,1-diphenyl-2-picrylhydrazyl2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acidalpha-AmylasesBenzamidesBenzothiazolesBiphenyl CompoundsEnzyme InhibitorsFree Radical ScavengersPicratesRhodanineSulfonic AcidsABTSDPPHIn silicoIn vitroKineticsRhodanineα-Amylase

Identifiers

PMID38446373

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.