ArticleInternal and emergency medicine2024
Renal arterial resistive index versus novel biomarkers for the early prediction of sepsis-associated acute kidney injury.
Article in Internal and emergency medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 15 citations in OpenAlex.
- Combined plasma syndecan-1 and renal resistive index as early predictors of sepsis-associated Acute kidney injury: a prospective observational study.Renal failure · 2026Observational
- The expanding role of ultrasound in acute kidney injury: from B-mode to microcirculation.Clinical kidney journal · 2026Review
- Diagnostic Significance of Renal Artery Resistive Index (RRI), Caudal Vena Cava Diameter (CVC), and Aorta (Ao) in Dogs with Hypovolemia.Veterinary sciences · 2026Article
- Early Renal Microcirculatory Perfusion Patterns in Sepsis: Associations with SA-AKI Trajectories in the Emergency Department.Diagnostics (Basel, Switzerland) · 2026Article
- Renal Resistive Index on Admission Predicts and Mediates Acute Kidney Injury: A Prospective Observational Study from a Greek Intensive Care Unit.Journal of clinical medicine · 2026Article
- Impact of sex on outcomes in septic shock patients treated with hydrocortisone.Scientific reports · 2025Observational
- The Usefulness of Peripheral and Organ Perfusion Monitoring in Predicting Mortality in Patients with Severe SARS-CoV-2.Biomedicines · 2025Article
- The diagnostic value of angiotensin, g-GT, blood lactate, and renal resistance index combined detection in acute kidney injury after neonatal asphyxia.Journal of medical biochemistry · 2025Article
- Identification of Key Genes and Potential Therapeutic Targets in Sepsis-Associated Acute Kidney Injury Using Transformer and Machine Learning Approaches.Bioengineering (Basel, Switzerland) · 2025Article
- The predictive value of renal vascular resistance index and serum biomarkers for sepsis-associated acute kidney injury: a retrospective study.BMC nephrology · 2025Article
- Acute Kidney Injury in Children Hospitalized with Unoperated Structural Congenital Heart Disease: Correspondence.Indian journal of pediatrics · 2025Article
- An Atypical Case of Rhabdomyolysis Following an Atypical Antidepressant Overdose.Journal of clinical medicine · 2025Article
- Impact of postoperative flurbiprofen axetil on renal function in spontaneously hypertensive rats.Frontiers in pharmacology · 2025Article
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6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is a critical complication of sepsis. There is a continuous need to identify and validate biomarkers for early detection. Serum and urinary biomarkers have been investigated, such as neutrophil gelatinase associated lipocalin (NGAL) and cystatin C (Cys C), but their reliability in the intensive care unit (ICU) remains unknown. Renal hemodynamics can be investigated by measuring the renal resistive index (RRI). This study aimed to compare the performance of RRI, serum NGAL (sNGAL), urinary NGAL (uNGAL), and serum Cys C levels as early predictors of the diagnosis and persistence of sepsis-associated AKI. A total of 166 adult patients with sepsis syndrome were enrolled immediately after ICU admission. Biomarkers were measured directly (T1) and on day 3 (T3). RRI was measured directly (T1) and 24 h later (T2). Patients were categorized (according to the occurrence and persistence of AKI within the first 7 days) into three groups: no AKI, transient AKI, and persistent AKI. The incidence rate of sepsis-associated AKI was 60.2%. Sixty-six patients were categorized as in the no AKI group, while another 61 were in transient AKI and only 39 were in persistent AKI. The RRI value (T1 ≥ 0.72) was the best tool for predicting AKI diagnosis (area under the receiver operating characteristic curve, AUROC = 0.905). Cys C (T1 ≥ 15.1 mg/l) was the best tool to predict the persistence of AKI (AUROC = 0.977). RRI (T1) was the best predictive tool for sepsis-associated AKI, while Cys C was the best predictor of its persistence and 28-day mortality.
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