Evidence map›Paper›PMID 38446324›Full record

ArticleBotanical studies2024

Hypoglycemic effects of dracorhodin and dragon blood crude extract from Daemonorops draco.

Yung-Hao Ching, Fang-Mei Lin, Hong-Chi Chen, Ching-Yun Hsu, Sze Yen P'ng, Tai-No Lin, Yu-Chia Wang, Cheng-Jun Lin, Yi-Chi Chen, Tsung-Jung Ho and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Botanical studies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yung-Hao ChingDepartment of Molecular Biology and Human Genetics, Tzu Chi University, 970374, Hualien, Taiwan.
Fang-Mei LinDepartment of Biochemistry, School of Medicine, Tzu Chi University, 701, Sec 3, Zhongyang Road, 970374, Hualien, Taiwan.
Hong-Chi ChenDepartment of Biomedical Sciences and Engineering, Tzu Chi University, 970374, Hualien, Taiwan.
Ching-Yun HsuDepartment of Molecular Biology and Human Genetics, Tzu Chi University, 970374, Hualien, Taiwan.
Sze Yen P'ngDepartment of Molecular Biology and Human Genetics, Tzu Chi University, 970374, Hualien, Taiwan.
Tai-No LinDepartment of Molecular Biology and Human Genetics, Tzu Chi University, 970374, Hualien, Taiwan.
Yu-Chia WangDepartment of Molecular Biology and Human Genetics, Tzu Chi University, 970374, Hualien, Taiwan.
Cheng-Jun LinDepartment of Molecular Biology and Human Genetics, Tzu Chi University, 970374, Hualien, Taiwan.
Yi-Chi ChenDepartment of Biochemistry, School of Medicine, Tzu Chi University, 701, Sec 3, Zhongyang Road, 970374, Hualien, Taiwan.
Tsung-Jung HoSchool of Post-Baccalaureate Chinese Medicine, Tzu Chi University, 970374, Hualien, Taiwan.
Hao-Ping ChenDepartment of Biochemistry, School of Medicine, Tzu Chi University, 701, Sec 3, Zhongyang Road, 970374, Hualien, Taiwan. hpchen@mail.tcu.edu.tw.ORCID http://orcid.org/0000-0002-6491-2178
Tzu Chi University · TW

Funding

Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation TCRD TCRD109-58
6 · The paper itself

Abstract

backgroundDragon blood is a red fruit resin from the palm tree Daemonorops draco and is a herbal ingredient used in the traditional Chinese medicine, "Jinchuang Ointment," which is used to treat non-healing diabetic wounds. According to the Taiwan Herbal Pharmacopeia, the dracorhodin content in dragon blood should exceed 1.0%.

resultsOur findings indicate that dracorhodin and dragon blood crude extracts can stimulate glucose uptake in mouse muscle cells (C2C12) and primary rat aortic smooth muscle cells (RSMC). Dracorhodin is not the only active compound in dragon blood crude extracts from D. draco. Next, we orally administered crude dragon blood extracts to male B6 mice. The experimental group displayed a decreasing trend in fasting blood glucose levels from the second to tenth week. In summary, crude extracts of dragon blood from D. draco demonstrated in vivo hypoglycemic effects in B6 male mice.

conclusionsWe provide a scientific basis "Jinchuang ointment" in treating non-healing wounds in patients with diabetes.

Indexed as

Blood glucoseDracorhodinDragon bloodJinchuang ointmentWound healing

Identifiers

PMID38446324
PMCPMC10917723
OpenAlexW4392518032

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.