Evidence map›Paper›PMID 38446190›Full record

ArticleEuropean journal of applied physiology2024

GH and IGF-1 in skin interstitial fluid and blood are associated with heat loss responses in exercising young adults.

Gulinu Maimaituxun, Tatsuro Amano, Glen P Kenny, Toby Mündel, Masanobu Kajiki, Kaname Tagawa, Akira Katagiri, Yoko Tanabe, Koichi Watanabe, Takeshi Nishiyasu and 2 more

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Article in European journal of applied physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Gulinu MaimaituxunInstitue of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8574, Japan.ORCID http://orcid.org/0000-0002-3272-0147
Tatsuro AmanoLaboratory for Exercise and Environmental Physiology, Faculty of Education, Niigata University, Niigata, Japan.ORCID http://orcid.org/0000-0001-9451-6937
Glen P KennyHuman and Environmental Physiology Research Unit, University of Ottawa, Ottawa, Canada.ORCID http://orcid.org/0000-0001-8683-6973
Toby MündelDepartment of Kinesiology, Brock University, St. Catharines, ON, Canada.ORCID http://orcid.org/0000-0002-4214-8543
Masanobu KajikiInstitue of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8574, Japan.
Kaname TagawaInstitue of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8574, Japan.
Akira KatagiriInstitue of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8574, Japan.ORCID http://orcid.org/0009-0001-1675-3141
Yoko TanabeJapan Society for the Promotion of Science, Tokyo, Japan.ORCID http://orcid.org/0000-0003-3105-2017
Koichi WatanabeInstitue of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8574, Japan.ORCID http://orcid.org/0000-0001-5439-9983
Takeshi NishiyasuInstitue of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8574, Japan.ORCID http://orcid.org/0000-0002-6040-7756
Narihiko KondoLaboratory for Applied Human Physiology, Graduate School of Human Development and Environment, Kobe University, Kobe, Japan.ORCID http://orcid.org/0000-0002-5623-408X
Naoto FujiiInstitue of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8574, Japan. fujii.naoto.gb@u.tsukuba.ac.jp.ORCID http://orcid.org/0000-0001-9696-8291
University of Tsukuba · JPBrock University · CAKobe University · JPNiigata University · JPToyo University · JPUniversity of Ottawa · CA

Funding

Japan Society for the Promotion of Science 20H04065
6 · The paper itself

Abstract

purposeSweat glands and cutaneous vessels possess growth hormone (GH) and insulin-like growth factor 1 (IGF-1) receptors. Here, we assessed if exercise increases GH and IGF-1 in skin interstitial fluid, and whether baseline and exercise-induced increases in GH and IGF-1 concentrations in skin interstitial fluid/blood are associated with heat loss responses of sweating and cutaneous vasodilation.

methodsSixteen young adults (7 women) performed a 50-min moderate-intensity exercise bout (50% VO

resultsExercise increased sweating and CVC (both P < 0.001), paralleled by increases of serum GH and skin dialysate GH and IGF-1 (all P ≤ 0.041) without changes in serum IGF-1. Sweating was positively correlated with baseline dialysate and serum GH levels, as well as exercise-induced increases in serum GH and IGF-1 (all P ≤ 0.044). Increases in CVC were not correlated with any GH and IGF-1 variables. Exogenous administration of GH and IGF-1 did not modulate resting sweat rate and CVC.

conclusion(1) Exercise increases GH and IGF-1 levels in the skin interstitial fluid, (2) exercise-induced sweating is associated with baseline GH in skin interstitial fluid and blood, as well as exercise-induced increases in blood GH and IGF-1, and (3) cutaneous vasodilation during exercise is not associated with GH and IGF-1 in skin interstitial fluid and blood.

Indexed as

ExerciseExtracellular FluidHuman Growth HormoneInsulin-Like Growth Factor ISkinAdultBody Temperature RegulationFemaleGrowth HormoneHumansMaleSweatingYoung AdultGrowth HormoneHuman Growth HormoneIGF1 protein, humanInsulin-Like Growth Factor IInterstitial fluidIntradermal microdialysisSomatotropinThermoregulation

Identifiers

PMID38446190
OpenAlexW4392512798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.