ArticleAbdominal radiology (New York)2024
Performance of CT in the locoregional staging of colon cancer: detailed radiology-pathology correlation with special emphasis on tumor deposits, extramural venous invasion and T staging.
Article in Abdominal radiology (New York), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Diagnostic accuracy of CT for identifying high-risk colon cancer: a systematic review and meta-analysis.European radiology · 2026Pooled it
- CT diagnostic performance for preoperative staging of colon cancer: a systematic review and meta-analysis.European radiology · 2026Pooled it
- CT-based radiogenomic analysis to predict high-risk colon cancer (ATTRACT): a multicentric trial.European radiology · 2025Trial
- CT staging performance in an international trial of neoadjuvant chemotherapy for locally advanced colon cancer.The British journal of radiology · 2025Trial
- CT-based radiomics signature for optimizing adjuvant chemotherapy decisions in stage II colorectal cancer with proficient mismatch repair.Abdominal radiology (New York) · 2026Article
- Development of a nomogram for predicting extramural venous invasion in colon cancer using spectral CT multiparameter imaging.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Current Status and Challenges of Imaging-Based Diagnosis of Lymph Node Metastasis in Colon Cancer: The Lymph Node Committee of the Japanese Society for Cancer of the Colon and Rectum.Annals of gastroenterological surgery · 2026Review
- Interpretable machine learning models based on CT radiomics for predicting chemoradiotherapy response in rectal cancer.BMC medical imaging · 2026Article
- Factors associated with lymph node metastasis and survival in T2 colon cancer.BMC gastroenterology · 2025Article
- LoG-staging: a rectal cancer staging method with LoG operator based on maximization of mutual information.BMC medical imaging · 2025Article
- Effects of Microsatellite Instability on the Clinical and Pathological Characteristics of Colon Cancer and the Diagnostic Accuracy of Preoperative Abdominal CT Scans.Diagnostics (Basel, Switzerland) · 2025Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the performance of computed tomography (CT) in the local staging of colon cancer in different segments, with emphasis on parameters that have been found to be significant for rectal cancer, namely, extramural venous invasion (EMVI) and tumor deposits (TDs).
methodsCT and pathology data from 137 patients were independently reviewed by radiology and pathology teams. The performance of CT in categorizing a given patient into good, versus poor prognostic groups was assessed for each segment, as well as the presence of lymph nodes (LNs), TDs and EMVIs. Discordant cases were re-evaluated to determine potential sources of error. Elastic stain was applied for EMVI discordance.
resultsThe T staging accuracy was 80.2%. For T stage stratification, CT performed slightly better in the left colon, and the lowest accuracy was in the transverse colon. Under-staging was more common (in 12.4%), and most of the mis-staged cases were in sigmoid colon. According to the first comprehensive correlative analysis, the sensitivity, specificity, and accuracy of CT for detecting TDs were found to be 57.9%, 92.4%, 87.6%, respectively. These figures were 44.7%, 72.7%, and 63.5% for LN, and 58.5%, 82.1% and 73% for EMVI. The detection rate was better for multifocal EMVI. The detection rate was also comparable (although substantially underestimated) for LNs, with the half of the LNs missed by CT being < 5 mm. Four patients that were classified as TD by CT, disclosed to be LNs by pathology. Correlative analysis led to refinement of the pathology criteria, with subsequent modifications of the initial reports in 13 (9.5%) patients.
conclusionOverall, CT performed well in the evaluation of colon cancer, as did TD and EMVI. It is advisable to include these parameters in CT-based staging. Radiologists should be aware of the pitfalls that occur more commonly in different segments.
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