Evidence map›Paper›PMID 38445877›Full record

ArticlemBio2024

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in

Kathleen R Nicholson, Rachel M Cronin, Rebecca J Prest, Aruna R Menon, Yuwei Yang, Madeleine K Jennisch, Matthew M Champion, David M Tobin, Patricia A Champion

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Pathogens (Basel, Switzerland) · 2025
    Review
  3. Journal of bacteriology · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kathleen R NicholsonDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0000-0002-6152-0259
Rachel M CroninDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Rebecca J PrestDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Aruna R MenonDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Yuwei YangDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Madeleine K JennischDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Matthew M ChampionDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0000-0001-5927-5277
David M TobinDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-3465-5518
Patricia A ChampionDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0000-0002-6733-596X
University of Notre Dame · USDuke University · US

Funding

Macrophage Reprogramming During Granuloma Formation in the ZebrafishR01AI130236 · NIAID · DUKE UNIVERSITY · PI David M. Tobin · 2017 to 2026
$4.5M
Genetic dissection of angiogenesis in the tuberculous granulomaR01AI125517 · NIAID · DUKE UNIVERSITY · PI David M. Tobin · 2017 to 2026
$4.4M
Role of N-alpha acetylation in mycobacterial secretion and virulenceR01AI106872 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHAMPION, PATRICIA A · 2013 to 2024
$4.2M
Chemistry-Biochemistry-Biology Training Program at Notre DameT32GM075762 · NIGMS · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F, MOBASHERY, SHAHRIAR · 2007 to 2021
$3.7M
Linking Human TB Genetic Susceptibility Loci to Granuloma BiologyR01AI166304 · NIAID · DUKE UNIVERSITY · PI David M. Tobin · 2022 to 2026
$3.4M
The Genetic Basis of Bone Disease in Mycobacterial InfectionR01AI127715 · NIAID · DUKE UNIVERSITY · PI Clare Margaret Smith, David M. Tobin · 2017 to 2026
$3.3M
Investigating the molecular requirements for ESX-1-lytic activity in pathogenic mycobacteriaR21AI156229 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHAMPION, PATRICIA A · 2021 to 2022
$430k
Mechanisms of ESX-1-dependent Gene Expression in Pathogenic MycobacteriaR21AI149235 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHAMPION, PATRICIA A · 2020 to 2021
$425k
The requirement for PDIM in mycobacterial protein secretionR03AI149147 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHAMPION, PATRICIA A · 2020 to 2021
$156k
NIAID NIH HHS R01 AI106872NIAID NIH HHS R01 AI125517NIAID NIH HHS R01 AI127715NIAID NIH HHS R01 AI130236NIAID NIH HHS R01 AI166304NIAID NIH HHS R03 AI149147NIAID NIH HHS R21 AI149235NIAID NIH HHS R21 AI156229NIGMS NIH HHS T32 GM075762
6 · The paper itself

Abstract

Bacterial pathogens use protein secretion systems to transport virulence factors and regulate gene expression. Among pathogenic mycobacteria, including

Indexed as

Mycobacterium marinumMycobacterium tuberculosisTuberculosisType VII Secretion SystemsAnimalsBacterial ProteinsTranscription FactorsZebrafishBacterial ProteinsTranscription FactorsType VII Secretion SystemsESX-1Mycobacteriumregulationtranscriptiontype VII secretion

Identifiers

PMID38445877
PMCPMC11005418
OpenAlexW4392519030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.