Evidence map›Paper›PMID 38445857›Full record

SynthesisMicrobiology spectrum2024

Evolutionary trends in antifungal resistance: a meta-analysis.

Xueke Niu, Abdullah M S Al-Hatmi, Roxana G Vitale, Michaela Lackner, Sarah A Ahmed, Paul E Verweij, Yingqian Kang, Sybren de Hoog

Abstract readMeta-Analysis
In one paragraph

Synthesis in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Structural barriers to antifungal drug development.Frontiers in cellular and infection microbiology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Establishment of epidemiological cutoff values forJournal of clinical microbiology · 2025
    Article
  8. Article
  9. A Comprehensive Analysis of the Lipidomic Signatures inJournal of fungi (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xueke NiuKey Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou & Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China.ORCID 0009-0005-3867-2210
Abdullah M S Al-HatmiCenter of Expertise in Mycology of Radboud University Medical Center/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.ORCID 0000-0002-5206-2647
Roxana G VitaleConsejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina.
Michaela LacknerInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Sarah A AhmedCenter of Expertise in Mycology of Radboud University Medical Center/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.ORCID 0000-0003-0155-8113
Paul E VerweijCenter of Expertise in Mycology of Radboud University Medical Center/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.ORCID 0000-0002-8600-9860
Yingqian KangKey Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou & Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China.ORCID 0009-0005-6033-447X
Sybren de HoogKey Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou & Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China.ORCID 0000-0002-5344-257X

Funding

111 Project D20009China National Tobacco Corporation (CNTC) [110202101048 (LS-08)]China Scholarship Council (CSC) 201908520049China-Ukraine Inthergovermental Exchange Project 8Foregin Experts Progect Category (G2021038009L)Guizhou High-leval Innovative Talent Category qiankeherencai-GCC[2022]036-1Guizhou Provincial Academician Workstation of Microbiology and Health No. [2020]4004Guizhou Scientific Plan Project [2020]4Y220International Science and Technology Cooperation Base of Guizhou Province [2020]4101MOST | National Natural Science Foundation of China (NSFC) no. 32060034Talent Base Project of Guizhou Province China [FCJD2018-22]
6 · The paper itself

Abstract

The present paper includes a meta-analysis of literature data on 318 species of fungi belonging to 34 orders in their response to 8 antifungal agents (amphotericin B, caspofungin, fluconazole, itraconazole, ketoconazole, posaconazole, terbinafine, and voriconazole). Main trends of MIC results at the ordinal level were visualized. European Committee on Antimicrobial Susceptibility Testing and Clinical & Laboratory Standards Institute (CLSI) clinical breakpoints were used as the staff gauge to evaluate MIC values ranging from resistance to susceptibility, which were subsequently compared with a phylogenetic tree of the fungal kingdom. Several orders ( IMPORTANCE: A kingdom-wide the largest set of published wild-type antifungal data comparison were analyzed. Trends in resistance in taxonomic groups (monophyletic clades) can be compared with the phylogeny of the fungal kingdom, eventual relationships between fungus-drug interaction and evolution can be described.

Indexed as

Antifungal AgentsFluconazoleAzolesDrug Resistance, FungalHumansMicrobial Sensitivity TestsPhylogenyVoriconazoleAntifungal AgentsAzolesFluconazoleVoriconazoleantifungalsbreakpointphylogenyresistance

Identifiers

PMID38445857
PMCPMC10986544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.