ArticleEuropean heart journal2024
Implantable loop recorders in patients with Brugada syndrome: the BruLoop study.
Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Supraventricular tachyarrhythmias in arrhythmogenic cardiomyopathy and Brugada syndrome: a systematic review.Frontiers in cardiovascular medicine · 2026Pooled it
- Multiparametric models for predicting major arrhythmic events in Brugada syndrome: a systematic review and critical appraisal.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Pooled it
- High-Risk ECG in Syncope: High Risk or Overstated?Journal of cardiovascular electrophysiology · 2026Article
- Sodium-channel blocker challenge unmasks Brugada syndrome in a 54-year-old male presenting with recurrent syncope and chronic cannabis use.HeartRhythm case reports · 2026Article
- Spontaneous ST-Segment Elevation in Right Precordial Leads Following Cardiac Arrest: Literature Review and Management Proposal for Ruling out Brugada Syndrome.Cardiovascular drugs and therapy · 2026Review
- Bradyarrhythmias and Brugada syndrome: clinical features, long-term outcome and prognostic implications-the BruBra study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Type 1 Brugada Pattern Triggered by Low-Grade Fever: Implications for Diagnosis and Risk Stratification.International journal of molecular sciences · 2026Article
- Contemporary Perspectives on J-Wave Syndromes: An Expert Consensus Statement.Journal of arrhythmia · 2026Article
- Impact of Atrial Fibrillation on the Outcome of Patients with Brugada Syndrome: A Meta-Analysis.Journal of cardiovascular development and disease · 2025Review
- Brugada syndrome.Nature reviews. Disease primers · 2025Review
- Psychological profile of patients with Brugada syndrome and the impact of its diagnosis and management.NPJ cardiovascular health · 2025Review
- Fever, Syncope, and the Brugada Dilemma: Navigating the Complexities of ICD Decision-Making in an Atypical Presentation.Case reports in cardiology · 2025Article
- aTrial arrhythmias in inhEriTed aRrhythmIa Syndromes: results from the TETRIS study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Increased pacemaker implantation and mortality rates in relatives of patients with early-onset sinus node dysfunction: can genetics explain all?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Asymptomatic Brugada syndrome: Navigating implantable cardioverter-defibrillator implantation dilemma.HeartRhythm case reports · 2024Article
- Inherited arrhythmia syndromes - Cardiogenetics.Indian pacing and electrophysiology journalReview
Corrections and comments
- Erratum issued
Authors and funding
39 authors at 18 institutions in 6 countries.
Funding
Abstract
BACKGROUND AND
aimsAvailable data on continuous rhythm monitoring by implantable loop recorders (ILRs) in patients with Brugada syndrome (BrS) are scarce. The aim of this multi-centre study was to evaluate the diagnostic yield and clinical implication of a continuous rhythm monitoring strategy by ILRs in a large cohort of BrS patients and to assess the precise arrhythmic cause of syncopal episodes.
methodsA total of 370 patients with BrS and ILRs (mean age 43.5 ± 15.9, 33.8% female, 74.1% symptomatic) from 18 international centers were included. Patients were followed with continuous rhythm monitoring for a median follow-up of 3 years.
resultsDuring follow-up, an arrhythmic event was recorded in 30.7% of symptomatic patients [18.6% atrial arrhythmias (AAs), 10.2% bradyarrhythmias (BAs), and 7.3% ventricular arrhythmias (VAs)]. In patients with recurrent syncope, the aetiology was arrhythmic in 22.4% (59.3% BAs, 25.0% VAs, and 15.6% AAs). The ILR led to drug therapy initiation in 11.4%, ablation procedure in 10.9%, implantation of a pacemaker in 2.5%, and a cardioverter-defibrillator in 8%. At multivariate analysis, the presence of symptoms [hazard ratio (HR) 2.5, P = .001] and age >50 years (HR 1.7, P = .016) were independent predictors of arrhythmic events, while inducibility of ventricular fibrillation at the electrophysiological study (HR 9.0, P < .001) was a predictor of VAs.
conclusionsILR detects arrhythmic events in nearly 30% of symptomatic BrS patients, leading to appropriate therapy in 70% of them. The most commonly detected arrhythmias are AAs and BAs, while VAs are detected only in 7% of cases. Symptom status can be used to guide ILR implantation.
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