Evidence map›Paper›PMID 38445701›Full record

ArticleCurrent medicinal chemistry2024

Unlocking the Immunomodulatory Potential of Rosmarinic Acid Isolated from

Rupesh K Gautam, Shailesh Mani Tripathi, Shopnil Akash, Sanjay Sharma, Komal Sharma, Swapnil Goyal, Sahar Behzad, Rohit Gundamaraju, Dinesh Kumar Mishra, Yingbo Zhang and 3 more

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Article in Current medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 6 countries.

Rupesh K GautamJoint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Shailesh Mani TripathiDepartment of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan, 333031, India.
Shopnil AkashDepartment of Pharmacy, Daffodil International University, Daffodil Smart City, Ashulia, Savar, Dhaka, 1207, Bangladesh.
Sanjay SharmaDepartment of Quality Assurance, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra, 400056, India.
Komal SharmaBhupal Nobles' College of Pharmacy, Bhopal Noble's University, Udaipur, 313001, India.
Swapnil GoyalFaculty of Pharmacy, Mandsaur University, Mandsaur, 458001, India.
Sahar BehzadEvidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Rohit GundamarajuER stress and mucosal immunology lab, School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.
Dinesh Kumar MishraDepartment of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University) Koni, Bilaspur (C.G.), 495009, India.
Yingbo ZhangJoint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Bairong ShenJoint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Sandeep SundriyalDepartment of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan, 333031, India.
Rajeev K SinglaJoint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0002-3353-7897
Sichuan University · CNBirla Institute of Technology and Science, Pilani · INLovely Professional University · INDaffodil International University · BDGuru Ghasidas Vishwavidyalaya · INJahrom University of Medical Sciences · IRNarsee Monjee Institute of Management Studies · INUniversity of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

aimThis study aimed to characterize an immunomodulatory compound isolated from Punica granatum L. using a bioactivity-guided approach.

methodsChromatographic techniques were adopted for isolation and purification of secondary metabolites.

resultsUsing preparative thin-layer chromatography, rosmarinic acid was isolated from F4 (column chromatography product obtained from a butanolic fraction of the extract). The impact of rosmarinic acid was assessed in rats using the neutrophil adhesion test, DTH response, and phagocytic index. In immunized rats, rosmarinic acid demonstrated significant immunomodulatory potential. Computational experiments, like molecular docking and molecular dynamics, were also conducted against two targeted receptors, Cereblon (PDB ID: 8AOQ) and human CD22 (PDB ID: 5VKM). Computational studies suggested that an increase in phagocytic index by rosmarinic acid could be attributed to inhibiting Cereblon and CD22. Pharmacokinetics and toxicity prediction also suggested the drug-likeness of rosmarinic acid.

conclusionRosmarinic acid is a potential candidate, but extensive research needs to be done to translate this molecule from bench to bedside.

Indexed as

CinnamatesDepsidesMolecular Docking SimulationPomegranateRosmarinic AcidAnimalsComputer SimulationHumansImmunologic FactorsImmunomodulating AgentsMaleMolecular Dynamics SimulationNeutrophilsPlant ExtractsRatsRats, WistarCinnamatesDepsidesImmunologic FactorsImmunomodulating AgentsPlant ExtractsRosmarinic AcidCD22Cereblonimmune response.immunomodulatory activityPunica granatum L.rosmarinic acid

Identifiers

PMID38445701
OpenAlexW4392517863

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.